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Helgadottir, Anna (author)

Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism

Article/chapterEnglish2012

Publisher, publication year, extent ...

Elsevier BV,2012

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LIBRIS-ID:oai:lup.lub.lu.se:17a9f062-dc3e-4135-95b2-d6f60c1d0114
https://lup.lub.lu.se/record/3055823URI
https://doi.org/10.1016/j.jacc.2012.01.078DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:125097305URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. Methods The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (ne = 4,572); venous thromboembolism (ne = 4,607); intracranial aneurysm (ne = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). Results LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 X 10(-4)), peripheral artery disease (OR: 1.47; p = 2.9 x 10(-14)), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 x 10(-5)), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 x 10(-12)). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (-1.58 years/allele; p = 8.2 x 10(-8)) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). Conclusions LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. (J Am Coll Cardiol 2012; 60: 722-9) (C) 2012 by the American College of Cardiology Foundation

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
association
atherosclerosis
genetic
lipoprotein(a)
thrombosis

Added entries (persons, corporate bodies, meetings, titles ...)

Gretarsdottir, Solveig (author)
Thorleifsson, Gudmar (author)
Holm, Hilma (author)
Patel, Riyaz S. (author)
Gudnason, Thorarinn (author)
Jones, Gregory T. (author)
van Rij, Andre M. (author)
Eapen, Danny J. (author)
Baas, Annette F. (author)
Tregouet, David-Alexandre (author)
Morange, Pierre-Emmanuel (author)
Emmerich, Joseph (author)
Lindblad, BengtLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups(Swepub:lu)kir-bli (author)
Gottsäter, AndersLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups(Swepub:lu)medf-ago (author)
Kiemeny, Lambertus A. (author)
Lindholt, Jes S. (author)
Sakalihasan, Natzi (author)
Ferrell, Robert E. (author)
Carey, David J. (author)
Elmore, James R. (author)
Tsao, Philip S. (author)
Grarup, Niels (author)
Jorgensen, Torben (author)
Witte, Daniel R. (author)
Hansen, Torben (author)
Pedersen, Oluf (author)
Pola, Roberto (author)
Gaetani, Eleonora (author)
Magnadottir, Hulda B. (author)
Wijmenga, Cisca (author)
Tromp, Gerard (author)
Ronkainen, Antti (author)
Ruigrok, Ynte M. (author)
Blankensteijn, Jan D. (author)
Mueller, Thomas (author)
Wells, Philip S. (author)
Corral, Javier (author)
Manuel Soria, Jose (author)
Carlos Souto, Juan (author)
Peden, John F. (author)
Jalilzadeh, Shapour (author)
Mayosi, Bongani M. (author)
Keavney, Bernard (author)
Strawbridge, Rona J.Karolinska Institutet (author)
Sabater-Lleal, MariaKarolinska Institutet (author)
Gertow, KarlKarolinska Institutet (author)
Baldassarre, Damiano (author)
Nyyssonen, Kristiina (author)
Rauramaa, Rainer (author)
Smit, Andries J. (author)
Mannarino, Elmo (author)
Giral, Philippe (author)
Tremoli, Elena (author)
de Faire, UlfKarolinska Institutet (author)
Humphries, Steve E. (author)
Hamsten, AndersKarolinska Institutet (author)
Haraldsdottir, Vilhelmina (author)
Olafsson, Isleifur (author)
Magnusson, Magnus K.Karolinska Institutet (author)
Samani, Nilesh J. (author)
Levey, Allan I. (author)
Markus, Hugh S. (author)
Kostulas, Konstantinos (author)
Dichgans, Martin (author)
Berger, Klaus (author)
Kuhlenbaeumer, Gregor (author)
Ringelstein, E. Bernd (author)
Stoll, Monika (author)
Seedorf, Udo (author)
Rothwell, Peter M. (author)
Powell, Janet T. (author)
Kuivaniemi, Helena (author)
Onundarson, Pall T. (author)
Valdimarsson, Einar (author)
Matthiasson, Stefan E. (author)
Gudbjartsson, Daniel F. (author)
Thorgeirsson, Guomundur (author)
Quyyumi, Arshed A. (author)
Watkins, Hugh (author)
Farrall, Martin (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
Vaskulära sjukdomar - kliniska studierForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Journal of the American College of Cardiology: Elsevier BV60:8, s. 722-7290735-10971558-3597

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By the author/editor: Helgadottir, Ann ...; Gretarsdottir, S ...; Thorleifsson, Gu ...; Holm, Hilma; Patel, Riyaz S.; Gudnason, Thorar ...; show more...; Jones, Gregory T ...; van Rij, Andre M ...; Eapen, Danny J.; Baas, Annette F.; Tregouet, David- ...; Morange, Pierre- ...; Emmerich, Joseph; Lindblad, Bengt; Gottsäter, Ander ...; Kiemeny, Lambert ...; Lindholt, Jes S.; Sakalihasan, Nat ...; Ferrell, Robert ...; Carey, David J.; Elmore, James R.; Tsao, Philip S.; Grarup, Niels; Jorgensen, Torbe ...; Witte, Daniel R.; Hansen, Torben; Pedersen, Oluf; Pola, Roberto; Gaetani, Eleonor ...; Magnadottir, Hul ...; Wijmenga, Cisca; Tromp, Gerard; Ronkainen, Antti; Ruigrok, Ynte M.; Blankensteijn, J ...; Mueller, Thomas; Wells, Philip S.; Corral, Javier; Manuel Soria, Jo ...; Carlos Souto, Ju ...; Peden, John F.; Jalilzadeh, Shap ...; Mayosi, Bongani ...; Keavney, Bernard; Strawbridge, Ron ...; Sabater-Lleal, M ...; Gertow, Karl; Baldassarre, Dam ...; Nyyssonen, Krist ...; Rauramaa, Rainer; Smit, Andries J.; Mannarino, Elmo; Giral, Philippe; Tremoli, Elena; de Faire, Ulf; Humphries, Steve ...; Hamsten, Anders; Haraldsdottir, V ...; Olafsson, Isleif ...; Magnusson, Magnu ...; Samani, Nilesh J ...; Levey, Allan I.; Markus, Hugh S.; Kostulas, Konsta ...; Dichgans, Martin; Berger, Klaus; Kuhlenbaeumer, G ...; Ringelstein, E. ...; Stoll, Monika; Seedorf, Udo; Rothwell, Peter ...; Powell, Janet T.; Kuivaniemi, Hele ...; Onundarson, Pall ...; Valdimarsson, Ei ...; Matthiasson, Ste ...; Gudbjartsson, Da ...; Thorgeirsson, Gu ...; Quyyumi, Arshed ...; Watkins, Hugh; Farrall, Martin; Thorsteinsdottir ...; Stefansson, Kari; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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