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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03782naa a2200505 4500 | |
| 001 | oai:lup.lub.lu.se:17ddbafe-dbc1-4af7-b383-9d7d4cc22b93 | |
| 003 | SwePub | |
| 008 | 160401s1998 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11138382 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Horger, B A4 aut |
| 245 | 1 0 | a Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons |
| 264 | 1 | c 1998 |
| 520 | a Glial cell line-derived neurotrophic factor (GDNF) exhibits potent effects on survival and function of midbrain dopaminergic (DA) neurons in a variety of models. Although other growth factors expressed in the vicinity of developing DA neurons have been reported to support survival of DA neurons in vitro, to date none of these factors duplicate the potent and selective actions of GDNF in vivo. We report here that neurturin (NTN), a homolog of GDNF, is expressed in the nigrostriatal system, and that NTN exerts potent effects on survival and function of midbrain DA neurons. Our findings indicate that NTN mRNA is sequentially expressed in the ventral midbrain and striatum during development and that NTN exhibits survival-promoting actions on both developing and mature DA neurons. In vitro, NTN supports survival of embryonic DA neurons, and in vivo, direct injection of NTN into the substantia nigra protects mature DA neurons from cell death induced by 6-OHDA. Furthermore, administration of NTN into the striatum of intact adult animals induces behavioral and biochemical changes associated with functional upregulation of nigral DA neurons. The similarity in potency and efficacy of NTN and GDNF on DA neurons in several paradigms stands in contrast to the differential distribution of the receptor components GDNF Family Receptor alpha1 (GFRalpha1) and GFRalpha2 within the ventral mesencephalon. These results suggest that NTN is an endogenous trophic factor for midbrain DA neurons and point to the possibility that GDNF and NTN may exert redundant trophic influences on nigral DA neurons acting via a receptor complex that includes GFRalpha1. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a GDNF | |
| 653 | a dopaminergic | |
| 653 | a trophic | |
| 653 | a Parkinson's | |
| 653 | a nigrostriatal | |
| 653 | a 6-OHDA | |
| 700 | 1 | a Nishimura, M C4 aut |
| 700 | 1 | a Armanini, M P4 aut |
| 700 | 1 | a Wang, L C4 aut |
| 700 | 1 | a Poulsen, K T4 aut |
| 700 | 1 | a Rosenblad, Carl4 aut |
| 700 | 1 | a Kirik, Denizu Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)mphy-dki |
| 700 | 1 | a Moffat, B4 aut |
| 700 | 1 | a Simmons, L4 aut |
| 700 | 1 | a Johnson, E Jr4 aut |
| 700 | 1 | a Milbrandt, J4 aut |
| 700 | 1 | a Rosenthal, A4 aut |
| 700 | 1 | a Björklund, Andersu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-abj |
| 700 | 1 | a Vandlen, R A4 aut |
| 700 | 1 | a Hynes, M A4 aut |
| 700 | 1 | a Phillips, H S4 aut |
| 710 | 2 | a Brain Repair and Imaging in Neural Systems (BRAINS)b Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t The Journal of Neuroscienceg 18:13, s. 4929-4937q 18:13<4929-4937x 1529-2401 |
| 856 | 4 | u http://www.jneurosci.org/cgi/content/full/18/13/4929y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1113838 |
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