Search: onr:"swepub:oai:lup.lub.lu.se:180847c8-04df-441e-9f44-0df943e887bd" >
Confirmation of ass...
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Bossini-Castillo, Lara
(author)
Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-08-28
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Oxford University Press (OUP),2011
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LIBRIS-ID:oai:lup.lub.lu.se:180847c8-04df-441e-9f44-0df943e887bd
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https://lup.lub.lu.se/record/2169320URI
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https://doi.org/10.1093/rheumatology/ker259DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123505007URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objectives. The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population.Methods. A total of 3800 SSc patients and 4282 healthy controls of white Caucasian ancestry from eight different European countries were included in the study. The MIF -173 single nucleotide polymorphism (SNP) was selected as genetic marker and genotyped using Taqman 5' allelic discrimination assay.Results. The MIF -173 SNP showed association with SSc [P = 0.04, odds ratio (OR) = 1.10, 95% CI 1.00, 1.19]. Analysis of the MIF -173 polymorphism according to SSc clinical phenotype revealed that the frequency of the -173*C allele was significantly higher in the dcSSc group compared with controls (P = 5.30E-03, OR = 1.21, 95% CI 1.07, 1.38). Conversely, the frequency of the MIF -173*C allele was significantly underrepresented in the lcSSc group compared with dcSSc patients, supporting previous findings [(P = 0.04, OR = 0.86, 95% CI 0.75, 0.99); meta-analysis including previous results (P = 0.005, OR = 0.83, 95% CI 0.73, 0.94)].Conclusion. Our results confirm the role of MIF -173 promoter polymorphism in SSc, and provide evidence of a strong association with the dcSSc subgroup of patients. Hence, the MIF -173 variant is confirmed as a promising clinical phenotype genetic marker.
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Simeon, Carmen P
(author)
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Beretta, Lorenzo
(author)
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Vonk, Madelon C
(author)
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Callejas-Rubio, José Luis
(author)
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Espinosa, Gerard
(author)
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Carreira, Patricia
(author)
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Camps, María T
(author)
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Rodríguez-Rodríguez, Luis
(author)
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Rodríguez-Carballeira, Mónica
(author)
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García-Hernández, Francisco J
(author)
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López-Longo, Francisco J
(author)
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Hernández-Hernández, Vanesa
(author)
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Sáez-Comet, Luis
(author)
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Egurbide, María Victoria
(author)
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Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-rhe
(author)
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Nordin, AnnikaKarolinska Institutet
(author)
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Hoffmann-Vold, Anna-Maria
(author)
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Vanthuyne, Marie
(author)
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Smith, Vanessa
(author)
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De Langhe, Ellen
(author)
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Kreuter, Alexander
(author)
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Riemekasten, Gabriela
(author)
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Witte, Torsten
(author)
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Hunzelmann, Nicolas
(author)
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Voskuyl, Alexandre E
(author)
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Schuerwegh, Annemie J
(author)
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Lunardi, Claudio
(author)
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Airó, Paolo
(author)
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Scorza, Raffaella
(author)
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Shiels, Paul
(author)
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van Laar, Jacob M
(author)
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Fonseca, Carmen
(author)
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Denton, Christopher
(author)
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Herrick, Ariane
(author)
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Worthington, Jane
(author)
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Koeleman, Bobby P
(author)
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Rueda, Blanca
(author)
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Radstake, Timothy R D J
(author)
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Martin, Javier
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Reumatologi och molekylär skelettbiologiSektion III
(creator_code:org_t)
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In:Rheumatology (Oxford, England): Oxford University Press (OUP)50, s. 1976-19811462-03321462-0324
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Beretta, Lorenzo
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Vonk, Madelon C
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Espinosa, Gerard
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Carreira, Patric ...
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Sáez-Comet, Luis
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Egurbide, María ...
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Hesselstrand, Ro ...
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Nordin, Annika
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Hoffmann-Vold, A ...
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Vanthuyne, Marie
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Smith, Vanessa
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De Langhe, Ellen
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Kreuter, Alexand ...
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Witte, Torsten
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Hunzelmann, Nico ...
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Voskuyl, Alexand ...
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Lunardi, Claudio
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Airó, Paolo
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van Laar, Jacob ...
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Fonseca, Carmen
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Herrick, Ariane
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