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Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves
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- Hansson, H A (author)
- University of Gothenburg
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- Dahlin, L B (author)
- University of Gothenburg
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- Danielsen, Nils (author)
- University of Gothenburg
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- (creator_code:org_t)
- Wiley, 1986
- 1986
- English 6 s.
- In: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 126:4, s. 14-609
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Female
- Fluorescent Antibody Technique
- Insulin-Like Growth Factor I
- Nerve Regeneration
- Peripheral Nerves
- Rats
- Rats, Inbred Strains
- Schwann Cells
- Sciatic Nerve
- Somatomedins
- Time Factors
- Journal Article
- Research Support, Non-U.S. Gov't
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
- Hansson, H A
- Dahlin, L B
- Danielsen, Nils
- Fryklund, L
- Nachemson, A K
- Polleryd, P
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- Rozell, Bjorn
- Skottner, Anna
- Stemme, S
- Lundborg, G
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- MEDICAL AND HEALTH SCIENCES
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- Lund University
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