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Adenovirus-mediated silencing of Synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets
- Iezzi, M (author)
-
- Eliasson, Lena (author)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
- Fukuda, M (author)
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- Wollheim, C B (author)
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- (creator_code:org_t)
- 2005-09-06
- 2005
- English.
- In: FEBS Letters. - : Wiley. - 1873-3468 .- 0014-5793. ; 579:23, s. 5241-5246
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Synaptotagmins (Syts) are involved in Ca2+-dependent insulin release. However, which Syt isoform is functional in primary beta-cells remains unknown. We demonstrate by electron microscopy of pancreatic islets, the association of Syt 9 with insulin granules. Silencing of Syt 9 by RNA interference adenovirus in islet cells had no effect on the expression of Syt 5, Syt 7 and Syt 3 isoforms. The latter was localized at the plasma membrane of pancreatic polypeptide cells. Insulin release in response to glucose or tolbutamide was strongly inhibited in Syt 9 deficient islets, whereas exocytosis potentiated by raising cAMP levels, was unaltered. Thus, Syt 9 may act as Ca2+ sensor for beta-cell secretion.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- insulin exocytosis
- pancreatic islets
- electron
- RNA
- microscopy
- interference
- beta-cell
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- art (subject category)
- ref (subject category)
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- Eliasson, Lena
- Fukuda, M
- Wollheim, C B
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- Lund University
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