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Synergism between v...
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
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Carmeliet, Peter (author)
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Moons, Lieve (author)
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Luttun, Aernout (author)
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Vincenti, Valeria (author)
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Compernolle, Veerle (author)
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De Mol, Maria (author)
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Wu, Yan (author)
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Bono, Françoise (author)
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Devy, Laetitia (author)
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Beck, Heike (author)
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Scholz, Dimitri (author)
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Acker, Till (author)
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DiPalma, Tina (author)
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Dewerchin, Mieke (author)
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Noel, Agnes (author)
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Stalmans, Ingeborg (author)
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Barra, Adriano (author)
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Blacher, Sylvia (author)
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Vandendriessche, Thierry (author)
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- Pontén, Annica (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Eriksson, Ulf (author)
- Karolinska Institutet
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Plate, Karl H. (author)
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Foidart, Jean-Michel (author)
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Schaper, Wolfgang (author)
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Charnock-Jones, D. Stephen (author)
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Hicklin, Daniel J. (author)
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Herbert, Jean-Marc (author)
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Collen, Désiré (author)
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Persico, M. Graziella (author)
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(creator_code:org_t)
- 2001-05-01
- 2001
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 7:5, s. 575-583
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Abstract
Subject headings
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- Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains unknown. Both VEGF and PlGF bind to VEGF receptor-1 (VEGFR-1), but it is unknown whether VEGFR-1, which exists as a soluble or a membrane-bound type, is an inert decoy or a signaling receptor for PlGF during angiogenesis. Here, we report that embryonic angiogenesis in mice was not affected by deficiency of PlGF (Pgf-/-). VEGF-B, another ligand of VEGFR-1, did not rescue development in Pgf-/- mice. However, loss of PlGF impaired angiogenesis, plasma extravasation and collateral growth during ischemia, inflammation, wound healing and cancer. Transplantation of wild-type bone marrow rescued the impaired angiogenesis and collateral growth in Pgf-/- mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow-derived cells. The synergism between PlGF and VEGF was specific, as PlGF deficiency impaired the response to VEGF, but not to bFGF or histamine. VEGFR-1 was activated by PlGF, given that anti-VEGFR-1 antibodies and a Src-kinase inhibitor blocked the endothelial response to PlGF or VEGF/PlGF. By upregulating PlGF and the signaling subtype of VEGFR-1, endothelial cells amplify their responsiveness to VEGF during the 'angiogenic switch' in many pathological disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Carmeliet, Peter
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Moons, Lieve
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Luttun, Aernout
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Vincenti, Valeri ...
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Compernolle, Vee ...
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De Mol, Maria
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show more...
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Wu, Yan
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Bono, Françoise
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Devy, Laetitia
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Beck, Heike
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Scholz, Dimitri
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Acker, Till
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DiPalma, Tina
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Dewerchin, Mieke
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Noel, Agnes
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Stalmans, Ingebo ...
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Barra, Adriano
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Blacher, Sylvia
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Vandendriessche, ...
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Pontén, Annica
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Eriksson, Ulf
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Plate, Karl H.
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Foidart, Jean-Mi ...
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Schaper, Wolfgan ...
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Charnock-Jones, ...
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Hicklin, Daniel ...
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Herbert, Jean-Ma ...
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Collen, Désiré
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Persico, M. Graz ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Medicine
- By the university
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Lund University
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Karolinska Institutet