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Estimating Global B...
Estimating Global Burden of Disease due to congenital anomaly : An analysis of European data
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- Boyle, Breidge (author)
- University of Ulster
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- Addor, Marie-Claude (author)
- Lausanne University Hospital
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- Arriola, Larraitz (author)
- Foundation for the Promotion of Health and Biomedical Research of Valencia Region
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- Barisic, Ingeborg (author)
- University of Zagreb
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- Bianchi, Fabrizio (author)
- Institute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT)
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- Csáky-Szunyogh, Melinda (author)
- Hungarian Congenital Abnormality Registry
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- de Walle, Hermien E.K. (author)
- University of Groningen
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- Dias, Carlos Matias (author)
- Registo Nacional de Anomalias Congénitas
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- Draper, Elizabeth (author)
- University of Leicester
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- Gatt, Miriam (author)
- Ministry for Health, Malta
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Garne, Ester (author)
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Haeusler, Martin (author)
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- Källén, Karin (author)
- Lund University,Lunds universitet,Miljöepidemiologi,Forskargrupper vid Lunds universitet,Tornbladinstitutet,Environmental Epidemiology,Lund University Research Groups,Tornblad Institute,Socialstyrelsen / Swedish National Board of Health and Welfare
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Latos-Bielenska, Anna (author)
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McDonnell, Bob (author)
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Mullaney, Carmel (author)
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Nelen, Vera (author)
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Neville, Amanda J. (author)
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O'Mahony, Mary (author)
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Queisser-Wahrendorf, Annette (author)
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Randrianaivo-Ranjatoelina, Hanitra (author)
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Rankin, Judith (author)
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Rissmann, Anke (author)
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Ritvanen, Annukka (author)
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Rounding, Catherine (author)
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Tucker, David (author)
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Verellen-Dumoulin, Christine (author)
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Wellesley, Diana (author)
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Wreyford, Ben (author)
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Zymak-Zakutnia, Natalia (author)
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Dolk, Helen (author)
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(creator_code:org_t)
- 2017-06-30
- 2018
- English.
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In: Archives of Disease in Childhood: Fetal and Neonatal Edition. - : BMJ. - 1359-2998 .- 1468-2052. ; 103:1, s. 22-28
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https://fn.bmj.com/c...
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https://doi.org/10.1...
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Abstract
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- Objective To validate the estimates of Global Burden of Disease (GBD) due to congenital anomaly for Europe by comparing infant mortality data collected by EUROCAT registries with the WHO Mortality Database, and by assessing the significance of stillbirths and terminations of pregnancy for fetal anomaly (TOPFA) in the interpretation of infant mortality statistics. Design, setting and outcome measures EUROCAT is a network of congenital anomaly registries collecting data on live births, fetal deaths from 20 weeks' gestation and TOPFA. Data from 29 registries in 19 countries were analysed for 2005-2009, and infant mortality (deaths of live births at age <1 year) compared with the WHO Mortality Database. Eight EUROCAT countries were excluded from further analysis on the basis that this comparison showed poor ascertainment of survival status. Results According to WHO, 17%-42% of infant mortality was attributed to congenital anomaly. In 11 EUROCAT countries, average infant mortality with congenital anomaly was 1.1 per 1000 births, with higher rates where TOPFA is illegal (Malta 3.0, Ireland 2.1). The rate of stillbirths with congenital anomaly was 0.6 per 1000. The average TOPFA prevalence was 4.6 per 1000, nearly three times more prevalent than stillbirths and infant deaths combined. TOPFA also impacted on the prevalence of postneonatal survivors with non-lethal congenital anomaly. Conclusions By excluding TOPFA and stillbirths from GBD years of life lost (YLL) estimates, GBD underestimates the burden of disease due to congenital anomaly, and thus declining YLL over time may obscure lack of progress in primary, secondary and tertiary prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Boyle, Breidge
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Addor, Marie-Cla ...
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Arriola, Larrait ...
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Barisic, Ingebor ...
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Bianchi, Fabrizi ...
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Csáky-Szunyogh, ...
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de Walle, Hermie ...
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Dias, Carlos Mat ...
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Draper, Elizabet ...
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Gatt, Miriam
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Garne, Ester
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Haeusler, Martin
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Källén, Karin
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Latos-Bielenska, ...
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McDonnell, Bob
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Mullaney, Carmel
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Nelen, Vera
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Neville, Amanda ...
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O'Mahony, Mary
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Queisser-Wahrend ...
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Randrianaivo-Ran ...
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Rankin, Judith
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Rissmann, Anke
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Ritvanen, Annukk ...
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Rounding, Cather ...
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Tucker, David
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Verellen-Dumouli ...
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Wellesley, Diana
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Wreyford, Ben
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Zymak-Zakutnia, ...
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Dolk, Helen
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