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β cell function and...
β cell function and insulin resistance have gender-specific correlations with carotid intima-media thickness in type 2 diabetes
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- Lu, Weifeng (author)
- Fudan University
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- Wang, Kai (author)
- Fudan University
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- Luo, Xiumei (author)
- Fudan University
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- Zhang, Silan (author)
- Fudan University
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- Zhou, Jingqi (author)
- Fudan University
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- Li, Shangjian (author)
- Fudan University
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- Chen, Ning (author)
- Fudan University
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- Luan, Cheng (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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(creator_code:org_t)
- English.
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In: International Journal of Diabetes in Developing Countries. - 0973-3930.
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- ObjectiveThe relationships between carotid intima-media thickness (C-IMT) and β cell function and insulin resistance in patients with type 2 diabetes (T2D) have not been fully elucidated. This study is to investigate whether impaired glucose metabolism is etiologically associated with C-IMT in patients with T2D.MethodsThe study group consisted of 490 (284 men, 206 women) participants. Venous blood specimens were obtained from all subjects for biochemical profiles after an >8-h overnight fast. C-IMT was measured as the distance between the luminal-intimal leading edge (I-line) and the medial-adventitial leading edge (M-line) on the far wall. Insulin resistance was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). The acute insulin response to arginine was calculated as the mean of the three plasma insulin levels obtained within 2, 4, and 6 min after the arginine bolus minus the pre-stimulus plasma insulin levels.ResultsThere was a graded increase in C-IMT values according to tertiles of HOMA-IR in men; the values of C-IMT were significantly decreased across the tertiles of acute insulin and C-peptide responses in women. Multivariate analysis revealed that HOMA-IR and age were positively associated with C-IMT among men participants, and acute insulin response and current smoking were the independent determinants of C-IMT in women.ConclusionEarly insulin response stimulated by arginine is independently associated with C-IMT in women T2D individuals, whereas insulin resistance is positively correlated with C-IMT in men T2D subjects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- β cell function
- insulin resistance
- Carotid Intima-Media Thickness
- Type 2 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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