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Pulmonary blood vol...
Pulmonary blood volume index as a quantitative biomarker of haemodynamic congestion in hypertrophic cardiomyopathy
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- Ricci, Fabrizio (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University G.d'Annunzio of Chieti-Pescara,Barts Health NHS Trust,Fondazione Villa Serena per La Ricerca,Queen Mary University
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- Aung, Nay (author)
- Queen Mary University,Barts Health NHS Trust
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- Thomson, Ross (author)
- Queen Mary University,Barts Health NHS Trust
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- Boubertakh, Redha (author)
- Queen Mary University,Barts Health NHS Trust
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- Camaioni, Claudia (author)
- Barts Health NHS Trust
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- Doimo, Sara (author)
- Barts Health NHS Trust,University Hospital Of Trieste,Queen Mary University
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- Sanghvi, Mihir M. (author)
- Barts Health NHS Trust,Queen Mary University
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- Fung, Kenneth (author)
- Queen Mary University,Barts Health NHS Trust
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- Khanji, Mohammed Y. (author)
- Queen Mary University,Barts Health NHS Trust
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- Lee, Aaron (author)
- Barts Health NHS Trust,Queen Mary University
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- Malcolmson, James (author)
- Barts Health NHS Trust,Queen Mary University
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- Mantini, Cesare (author)
- University G.d'Annunzio of Chieti-Pescara
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- Paiva, José (author)
- Queen Mary University,Barts Health NHS Trust
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- Gallina, Sabina (author)
- University G.d'Annunzio of Chieti-Pescara
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- Fedorowski, Artur (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Mohiddin, Saidi A. (author)
- Queen Mary University,Barts Health NHS Trust
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- Aquaro, Giovanni Donato (author)
- Gabriele Monasterio Foundation
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- Petersen, Steffen E. (author)
- Queen Mary University,Barts Health NHS Trust
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(creator_code:org_t)
- 2019-08-29
- 2019
- English 9 s.
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In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2412 .- 2047-2404. ; 20:12, s. 1368-1376
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Abstract
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- AIMS : The non-invasive assessment of left ventricular (LV) diastolic function and filling pressure in hypertrophic cardiomyopathy (HCM) is still an open issue. Pulmonary blood volume index (PBVI) by cardiovascular magnetic resonance (CMR) has been proposed as a quantitative biomarker of haemodynamic congestion. We aimed to assess the diagnostic accuracy of PBVI for left atrial pressure (LAP) estimation in patients with HCM. METHODS AND RESULTS : We retrospectively identified 69 consecutive HCM outpatients (age 58 ± 11 years; 83% men) who underwent both transthoracic echocardiography (TTE) and CMR. Guideline-based detection of LV diastolic dysfunction was assessed by TTE, blinded to CMR results. PBVI was calculated as the product of right ventricular stroke volume index and the number of cardiac cycles for a bolus of gadolinium to pass through the pulmonary circulation as assessed by first-pass perfusion imaging. Compared to patients with normal LAP, patients with increased LAP showed significantly larger PBVI (463 ± 127 vs. 310 ± 86 mL/m2, P < 0.001). PBVI increased progressively with worsening New York Heart Association functional class and echocardiographic stages of diastolic dysfunction (P < 0.001 for both). At the best cut-off point of 413 mL/m2, PBVI yielded good diagnostic accuracy for the diagnosis of LV diastolic dysfunction with increased LAP [C-statistic = 0.83; 95% confidence interval (CI): 0.73-0.94]. At multivariable logistic regression analysis, PBVI was an independent predictor of increased LAP (odds ratio per 10% increase: 1.97, 95% CI: 1.06-3.68; P = 0.03). CONCLUSION : PBVI is a promising CMR application for assessment of diastolic function and LAP in patients with HCM and may serve as a quantitative marker for detection, grading, and monitoring of haemodynamic congestion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiovascular magnetic resonance
- diastolic dysfunction
- echocardiography
- hypertrophic cardiomyopathy
- pulmonary blood volume
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ricci, Fabrizio
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Aung, Nay
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Thomson, Ross
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Boubertakh, Redh ...
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Camaioni, Claudi ...
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Doimo, Sara
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Sanghvi, Mihir M ...
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Fung, Kenneth
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Khanji, Mohammed ...
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Lee, Aaron
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Malcolmson, Jame ...
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Mantini, Cesare
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Paiva, José
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Gallina, Sabina
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Fedorowski, Artu ...
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Mohiddin, Saidi ...
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Aquaro, Giovanni ...
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Petersen, Steffe ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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European Heart J ...
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Lund University