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Protein Z and protein Z-dependent protease inhibitor - Determinants of levels and risk of venous thrombosis
- Al-Shanqeeti, A (author)
- Vlieg, AV (author)
-
- Berntorp, Erik (author)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups
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- Rosendaal, FR (author)
- Broze, GJ (author)
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- (creator_code:org_t)
- 2005
- 2005
- English.
- In: Thrombosis and Haemostasis. - 0340-6245. ; 93:3, s. 411-413
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- thrombophilia
- coagulation inhibitors
- clinical/epidemiological studies
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Vlieg, AV
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- Broze, GJ
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