The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study

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MARC

Rutters, FemkeVrije Universiteit Amsterdam (author)

The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study

Article/chapterEnglish2016

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The Endocrine Society,2016
9 s.

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LIBRIS-ID:oai:lup.lub.lu.se:196b87b3-7b9e-4893-a054-cb67e5ebbb5f
https://lup.lub.lu.se/record/196b87b3-7b9e-4893-a054-cb67e5ebbb5fURI
https://doi.org/10.1210/jc.2016-1045DOI

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Language:English
Summary in:English

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Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort. Design, Setting, Participants, and Measures:Weused data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer. Insulin sensitivity and β-cell function were estimated by hyperinsulinemic-euglycemic clamp and from the oral glucose insulin sensitivity index model, using an oral glucose tolerance test. Associations of sleep duration with insulin sensitivity and β-cell function were analyzed by multiple linear regression, stratified by sex. Results: In our current analysis, we included 788 participants (57% women, age 44±8 y), who had an average sleep duration of 7.3±1.5 hours. In men,weobserved an inverted U-shaped association between sleep duration categorized per hour and M/I (in μmol/min per kgFFM/nM per hour) (±- estimate [95% confidence intervals] 41 [2, 80]; P = .04 and β2-estimate -3 [-6, -0.2], P = .04) as well as a trend for the oral glucose insulin sensitivity index (in mL/min per kgFFM) (β-estimate [95% confidence intervals] 0.8 [-0.4, 2]; P = .17). In women, we observed a U-shaped association between sleep duration and β-cell function (in pmol/min perm2/mM per hour) (β-estimate-45 [-86, -3]; P = .04 and β2-estimate 3 [0.2, 6]; P = .04). Conclusions: Sleep duration is associated with insulin sensitivity and β-cell function in a sex-specific manner in clinically healthy people.

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Besson, HervePHARMO Institute for Drug Outcome Research (author)
Walker, MarkUniversity of Newcastle upon Tyne (author)
Mari, AndreaCNR: National Research Council of Italy (author)
Konrad, ThomasInstitute of Metabolic Research Frankfurt (author)
Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
Balkau, BeverleyCenter For Immunology Of Viral Infections And Autoimmune Diseases (author)
Dekker, Jacqueline M.Vrije Universiteit Amsterdam (author)
Vrije Universiteit AmsterdamPHARMO Institute for Drug Outcome Research (creator_code:org_t)

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In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society101:9, s. 3272-32800021-972X1945-7197

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