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Plasminogen is a cr...
Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2004
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:1a18611a-23d2-4503-8471-27d99fe6967e
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https://lup.lub.lu.se/record/270682URI
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https://doi.org/10.1126/science.1101245DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.
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Ringdahl, UlrikaLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)mmb-uri
(author)
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Homeister, JW
(author)
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Fay, WP
(author)
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Engleberg, NC
(author)
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Yang, AY
(author)
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Rozek, LS
(author)
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Wang, XX
(author)
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Sjöbring, UlfLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-usj
(author)
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Ginsburg, D
(author)
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Institutionen för immunteknologiInstitutioner vid LTH
(creator_code:org_t)
Related titles
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In:Science: American Association for the Advancement of Science (AAAS)305:5688, s. 1283-12861095-92030036-8075
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Sun, HM
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Ringdahl, Ulrika
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Homeister, JW
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Fay, WP
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Engleberg, NC
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Yang, AY
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Rozek, LS
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Wang, XX
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Sjöbring, Ulf
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Ginsburg, D
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Lund University