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A novel gene family...
A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon
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- Lundwall, Åke (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Lazure, C. (author)
- Lund University
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(creator_code:org_t)
- 1995
- 1995
- English.
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In: FEBS Letters. - 1873-3468. ; 374:1, s. 6-53
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Abstract
Subject headings
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- Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- *Prostatic Secretory Proteins
- *Multigene Family
- Molecular Sequence Data
- Male
- Humans
- Guinea Pigs
- Gonadal Steroid Hormones/genetics
- *Exons
- Molecular
- *Evolution
- Dna
- Conserved Sequence
- Animals
- Base Sequence
- Proteins/*genetics
- Rats
- Research Support
- Non-U.S. Gov't
- *Semen
- Seminal Plasma Proteins
- Seminal Vesicle Secretory Proteins
- Sequence Homology
- Nucleic Acid
Publication and Content Type
- art (subject category)
- ref (subject category)
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