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The Functional Poly...
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Broen, Jasper C A
(author)
The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2010-12-15
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The Journal of Rheumatology,2011
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LIBRIS-ID:oai:lup.lub.lu.se:1ab2ba5c-994a-4e30-b59c-5bac837d9d58
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https://lup.lub.lu.se/record/1756290URI
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https://doi.org/10.3899/jrheum.100427DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
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Coenen, Marieke J H
(author)
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Rueda, Blanca
(author)
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Witte, Torsten
(author)
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Padyukov, Leonid
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Klareskog, Lars
(author)
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Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-rhe
(author)
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Wuttge, DirkLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-dwu
(author)
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Simeon, Carmen
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Ortego-Centeno, Norberto
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González-Gay, Miguel
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Pros, Anna
(author)
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Hunzelman, Nicholas
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Riemekasten, Gabriela
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Kreuter, Alexander
(author)
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Vonk, Madelon
(author)
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Scorza, Rafaella
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Beretta, Lorenzo
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Airò, Paulo
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van Riel, Piet L C M
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Kimberly, Robert
(author)
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Martin, Javier
(author)
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Edberg, Jeffrey
(author)
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Radstake, Timothy R D J
(author)
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Reumatologi och molekylär skelettbiologiSektion III
(creator_code:org_t)
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In:Journal of Rheumatology: The Journal of Rheumatology38:3, s. 446-4490315-162X1499-2752
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Broen, Jasper C ...
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Coenen, Marieke ...
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Rueda, Blanca
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Witte, Torsten
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Padyukov, Leonid
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Klareskog, Lars
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Hesselstrand, Ro ...
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Wuttge, Dirk
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Simeon, Carmen
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Ortego-Centeno, ...
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González-Gay, Mi ...
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Pros, Anna
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Hunzelman, Nicho ...
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Riemekasten, Gab ...
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Kreuter, Alexand ...
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Vonk, Madelon
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Scorza, Rafaella
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Beretta, Lorenzo
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Airò, Paulo
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van Riel, Piet L ...
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Kimberly, Robert
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Martin, Javier
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Edberg, Jeffrey
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Radstake, Timoth ...
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