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Search: onr:"swepub:oai:lup.lub.lu.se:1ab2ba5c-994a-4e30-b59c-5bac837d9d58" > The Functional Poly...

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  • Broen, Jasper C A (author)

The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2010-12-15
  • The Journal of Rheumatology,2011

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1ab2ba5c-994a-4e30-b59c-5bac837d9d58
  • https://lup.lub.lu.se/record/1756290URI
  • https://doi.org/10.3899/jrheum.100427DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

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  • Coenen, Marieke J H (author)
  • Rueda, Blanca (author)
  • Witte, Torsten (author)
  • Padyukov, Leonid (author)
  • Klareskog, Lars (author)
  • Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-rhe (author)
  • Wuttge, DirkLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-dwu (author)
  • Simeon, Carmen (author)
  • Ortego-Centeno, Norberto (author)
  • González-Gay, Miguel (author)
  • Pros, Anna (author)
  • Hunzelman, Nicholas (author)
  • Riemekasten, Gabriela (author)
  • Kreuter, Alexander (author)
  • Vonk, Madelon (author)
  • Scorza, Rafaella (author)
  • Beretta, Lorenzo (author)
  • Airò, Paulo (author)
  • van Riel, Piet L C M (author)
  • Kimberly, Robert (author)
  • Martin, Javier (author)
  • Edberg, Jeffrey (author)
  • Radstake, Timothy R D J (author)
  • Reumatologi och molekylär skelettbiologiSektion III (creator_code:org_t)

Related titles

  • In:Journal of Rheumatology: The Journal of Rheumatology38:3, s. 446-4490315-162X1499-2752

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