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The prevalence of r...
The prevalence of renal amyloidosis of the AA-type in a series of 1,158 consecutive autopsies
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- Löfberg, Helge (author)
- Skåne University Hospital
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- Grubb, Anders (author)
- Skåne University Hospital
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- Thysell, Hans (author)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Nilsson, Elise (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Patologi, Malmö,Urological cancer, Malmö,Lund University Research Groups,Pathology, Malmö,Skåne University Hospital
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- Kjellander, Birgitta (author)
- Skåne University Hospital,Lund University
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- Möller, Christina (author)
- Skåne University Hospital
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- Gruic, Vinka (author)
- Skåne University Hospital
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- Ljungquist, Anne (author)
- Skåne University Hospital
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- Sternby, Nils H. (author)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2009-08-19
- 1987
- English.
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In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. - : Wiley. - 0108-0164. ; 95A:1-6, s. 297-302
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Abstract
Subject headings
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- To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean age at death of the individuals with the AA-type of amyloidosis was 79 years. Six of the cases with amyloidosis had rheumatoid arthritis. The avidin-biotin-peroxidase complex technique was found to be superior to the immunofluorescence method and a high sensitivity and specificity was achieved when sequence-specific antibodies against a synthetized nonapeptide corresponding to a hydrophilic segment of the polypeptide chain of protein AA were used in the assay. Nine cases with other types of amyloid deposits in the kidneys were also detected. None of these cases showed any AA immunoreactivity but all of them demonstrated Congophilic deposits which were immunohistochemically stained by antibodies against the amyloid P-component. The prevalence of renal amyloidosis comprising all types of amyloid protein deposits was 1.64 per cent.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Aged
- Aged, 80 and over
- Amyloidosis/epidemiology
- Autopsy
- Female
- Fluorescent Antibody Technique
- Humans
- Immunoenzyme Techniques
- Kidney Diseases/epidemiology
- Male
- Middle Aged
- Serum Amyloid A Protein/analysis
Publication and Content Type
- art (subject category)
- ref (subject category)
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