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Increased lymphocyt...
Increased lymphocyte activation and atherosclerosis in CD47-deficient mice
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- Engelbertsen, Daniel (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups,Brigham and Women's Hospital / Harvard Medical School,Skåne University Hospital
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- Autio, Anu (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Verwilligen, Robin A.F. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Depuydt, Marie A.C. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Newton, Gail (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Rattik, Sara (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups,Skåne University Hospital
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- Levinsohn, Erik (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Saggu, Gurpanna (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Jarolim, Petr (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Wang, Huan (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Velazquez, Francisco (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Lichtman, Andrew H. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Luscinskas, Francis W. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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(creator_code:org_t)
- 2019-07-23
- 2019
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- CD47, also known as integrin-associated protein (IAP), is a transmembrane protein with multiple biological functions including regulation of efferocytosis and leukocyte trafficking. In this study we investigated the effect of CD47-deficiency on atherosclerosis using a model of adeno-associated virus (AAV)-induced hypercholesterolemia. We observed increased plaque formation in CD47 null mice compared to wild-type controls. Loss of CD47 caused activation of dendritic cells, T cells and natural killer (NK) cells, indicating an important role for CD47 in regulating immunity. In particular, Cd47 deficiency increased the proportion of IFN-γ producing CD90+ NK cells. Treatment with depleting anti-NK1.1 monoclonal antibody (mAb), but not depleting anti-CD4/CD8 mAbs, equalized atherosclerotic burden, suggesting NK cells were involved in the enhanced disease in Cd47 deficient mice. Additional studies revealed that levels of CD90+ and IFN-γ+ NK cells were expanded in atherosclerotic aorta and that CD90+ NK cells produce more IFN-γ than CD90- NK cells. Finally, we demonstrate that anti-CD47 (MIAP410) causes splenomegaly and activation of DCs and T cells, without affecting NK cell activation. In summary, we demonstrate that loss of CD47 causes increased lymphocyte activation that results in increased atherosclerosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- Av författaren/redakt...
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Engelbertsen, Da ...
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Autio, Anu
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Verwilligen, Rob ...
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Depuydt, Marie A ...
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Newton, Gail
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Rattik, Sara
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visa fler...
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Levinsohn, Erik
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Saggu, Gurpanna
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Jarolim, Petr
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Wang, Huan
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Velazquez, Franc ...
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Lichtman, Andrew ...
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Luscinskas, Fran ...
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visa färre...
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