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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04007naa a2200505 4500 | |
| 001 | oai:DiVA.org:uu-113955 | |
| 003 | SwePub | |
| 008 | 100205s2008 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:219085233 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1139552 URI |
| 024 | 7 | a https://doi.org/10.1080/138134508025424952 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2190852332 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Singh, Umashankaru Uppsala universitet,Zoologisk utvecklingsbiologi4 aut0 (Swepub:uu)umsin087 |
| 245 | 1 0 | a Characterization of a novel obesity phenotype caused by interspecific hybridization. |
| 264 | c 2009-01-05 | |
| 264 | 1 | b Informa UK Limited,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Interspecific hybridization in mammals causes hybrid dysgenesis effects, such as sterility and abnormal placentation. Here, we describe a novel obesity syndrome caused by interspecific hybridization in the genus Mus and show that this obesity, appearing sporadically in F1 littermates derived from inbred strains, has an epigenetic basis. Mus hybrids from various strains of M. musculus and M. spretus were generated and the sporadic obese phenotype was confirmed through assessment of physiological and biochemical parameters in littermates. To understand the underlying mechanisms, large-scale and candidate gene expression assays, global DNA methylation assays and allelic expression analysis were performed. Studies showed that obese hybrids are similar to other known models of obesity. While increased axial growth indicated a defect in POMC pathway, comparison of global gene expression patterns in brain of obese F1 and obese Pomc mutant mice showed little similarity. In F1 obese mice many genes involved in the maintenance of epigenetic states, as well as several imprinted genes, were differentially expressed. Global DNA methylation analysis in brain showed that increased methylation levels were associated with obesity. The imprinted gene Gnasxl, known to be important in lipid homeostasis, was found over expressed in the obese hybrids. Allelic expression and methylation analysis of Gnasxl showed that alterations of epigenetic marks underlying F1 obesity are probably many and multi-factorial. CONCLUSIONS: This model of obesity, which is both spontaneous and epigenetic, may be a useful tool to address the epigenetic aspects of clinical obesity. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Zoologi0 (SwePub)106082 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Zoology0 (SwePub)106082 hsv//eng |
| 653 | a Biology | |
| 653 | a Biologi | |
| 653 | a Animal physiology | |
| 653 | a Zoofysiologi | |
| 700 | 1 | a Rizvi, Farhanu Uppsala universitet,Zoologisk utvecklingsbiologi4 aut |
| 700 | 1 | a Yu, Yangu Uppsala universitet,Zoologisk utvecklingsbiologi4 aut0 (Swepub:uu)yanyu758 |
| 700 | 1 | a Shi, Weiu Uppsala universitet,Zoologisk utvecklingsbiologi4 aut |
| 700 | 1 | a Orth, Annie4 aut |
| 700 | 1 | a Karimi, Mohsenu Karolinska Institutet4 aut |
| 700 | 1 | a Ekström, Tomas Ju Karolinska Institutet4 aut |
| 700 | 1 | a Plagge, Antonius4 aut |
| 700 | 1 | a Kelsey, Gavin4 aut |
| 700 | 1 | a Fundele, Reinaldu Uppsala universitet,Zoologisk utvecklingsbiologi4 aut0 (Swepub:uu)refun535 |
| 710 | 2 | a Uppsala universitetb Zoologisk utvecklingsbiologi4 org |
| 773 | 0 | t Archives of Physiology and Biochemistryd : Informa UK Limitedg 114:5, s. 301-330q 114:5<301-330x 1381-3455x 1744-4160 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113955 |
| 856 | 4 8 | u https://doi.org/10.1080/13813450802542495 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:219085233 |
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