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Brain energy metabo...
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Rae, Caroline D.University of New South Wales
(author)
Brain energy metabolism : A roadmap for future research
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LIBRIS-ID:oai:lup.lub.lu.se:1b6c1b53-7c3e-4e1e-bfa5-da409ba6e3eb
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https://lup.lub.lu.se/record/1b6c1b53-7c3e-4e1e-bfa5-da409ba6e3ebURI
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https://doi.org/10.1111/jnc.16032DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD+, as well as unsolved problems underlying brain metabolism in pathologies such as traumatic brain injury, epilepsy, and metabolic downregulation during hibernation. It describes our current level of understanding of these facets of brain energy metabolism as well as a roadmap for future research.
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Baur, Joseph A.University of Pennsylvania
(author)
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Borges, KarinUniversity of Queensland
(author)
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Dienel, GeraldUniversity of New Mexico School of Medicine
(author)
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Díaz-García, Carlos Manlio
(author)
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Douglass, Starlette R.University at Albany, SUNY
(author)
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Drew, KellyUniversity of Alaska Fairbanks
(author)
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Duarte, João M NLund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)jo2654du
(author)
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Duran, JordiRamon Llull University,Institute for Bioengineering of Catalonia (IBEC)
(author)
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Kann, OliverHeidelberg University
(author)
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Kristian, TiborUniversity of Maryland School of Medicine
(author)
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Lee-Liu, Dasfne
(author)
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Lindquist, Britta E.University of California, San Francisco
(author)
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McNay, Ewan C.University at Albany, SUNY
(author)
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Robinson, Michael B.The Children's Hospital of Philadelphia
(author)
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Rothman, Douglas L.Yale University
(author)
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Rowlands, Benjamin D.University of Sydney
(author)
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Ryan, Timothy A.Weill Cornell Medical College
(author)
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Scafidi, JosephJohns Hopkins University School of Medicine
(author)
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Scafidi, SusannaJohns Hopkins University School of Medicine
(author)
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Shuttleworth, C. WilliamUniversity of New Mexico School of Medicine
(author)
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Swanson, Raymond A.University of California, San Francisco
(author)
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Uruk, GökhanUniversity of California, San Francisco
(author)
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Vardjan, Nina
(author)
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Zorec, Robert
(author)
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McKenna, Mary C.University of Maryland School of Medicine
(author)
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University of New South WalesUniversity of Pennsylvania
(creator_code:org_t)
Related titles
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In:Journal of Neurochemistry0022-3042
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- By the author/editor
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Rae, Caroline D.
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Baur, Joseph A.
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Borges, Karin
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Dienel, Gerald
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Díaz-García, Car ...
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Douglass, Starle ...
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show more...
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Drew, Kelly
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Duarte, João M N
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Duran, Jordi
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Kann, Oliver
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Kristian, Tibor
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Lee-Liu, Dasfne
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Lindquist, Britt ...
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McNay, Ewan C.
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Robinson, Michae ...
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Rothman, Douglas ...
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Rowlands, Benjam ...
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Ryan, Timothy A.
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Scafidi, Joseph
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Scafidi, Susanna
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Shuttleworth, C. ...
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Swanson, Raymond ...
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Uruk, Gökhan
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Vardjan, Nina
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Zorec, Robert
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McKenna, Mary C.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Journal of Neuro ...
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Lund University