Search: onr:"swepub:oai:lup.lub.lu.se:1bb31c16-60bd-4567-9d54-23f1b4db4c2c" >
Dual antiplatelet U...
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Kim, Joon TaeChonnam National University
(author)
Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial : Rationale and design
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-28
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SAGE Publications,2023
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:1bb31c16-60bd-4567-9d54-23f1b4db4c2c
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https://lup.lub.lu.se/record/1bb31c16-60bd-4567-9d54-23f1b4db4c2cURI
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https://doi.org/10.1177/17474930231168742DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited to detect a statistically significant relative risk reduction of 22% with 80% power and a two-sided alpha error of 0.05, including a 10% loss to follow-up. This is a registry-based, multicenter, prospective, randomized, open-label, blinded end point study designed to evaluate the efficacy and safety of a 12-month duration of DAPT compared with a 3-month duration of DAPT in the LAA stroke subtype. Patients will be randomized (1:1) to either DAPT for 12 months or DAPT for 3 months, followed by monotherapy (either aspirin or clopidogrel) for the remaining 9 months. Study outcomes: The primary efficacy outcome of the study is a composite of stroke (ischemic or hemorrhagic), myocardial infarction, and all-cause mortality for 1 year after the index stroke. The secondary efficacy outcomes are (1) stroke, (2) ischemic stroke or transient ischemic attack, (3) hemorrhagic stroke, and (4) all-cause mortality. The primary safety outcome is major bleeding. Discussion: This study will help stroke physicians determine the appropriate duration of dual therapy with clopidogrel-aspirin for patients with the LAA stroke subtype. Trial registration: URL: https://cris.nih.go.kr/cris. CRIS Registration Number: KCT0004407.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kang, JihoonSeoul National University
(author)
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Kim, Beom JoonSeoul National University
(author)
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Kim, Jun YupSeoul National University
(author)
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Han, Moon Ku
(author)
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Cho, Ki Hyun
(author)
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Park, Man Seok
(author)
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Choi, Kang Ho
(author)
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Park, Jong MooEulji University School of Medicine
(author)
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Kang, Kyusik
(author)
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Kim, Yong Soo
(author)
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Lee, Soo Joo
(author)
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Kim, Jae Guk
(author)
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Cha, Jae KwanDong-a University Hospital
(author)
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Kim, Dae HyunDong-a University Hospital
(author)
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Park, Tai Hwan
(author)
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Park, Sang Soon
(author)
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Choi, Jin Kyo
(author)
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Lee, Kyungbok
(author)
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Park, Kwang YeolChung-Ang University
(author)
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Jeong, Hae BongChung-Ang University
(author)
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Lee, Jun
(author)
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Kwon, Doo Hyuk
(author)
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Cho, Yong JinInje University
(author)
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Hong, Keun SikInje University
(author)
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Park, Hong KyunInje University
(author)
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Lee, Byung ChulHallym University
(author)
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Yu, Kyung HoHallym University
(author)
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Oh, Mi SunHallym University
(author)
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Lee, MinwooHallym University
(author)
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Kim, Dong Eog
(author)
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Gwak, Dong Seok
(author)
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Choi, Jay Chol
(author)
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Kim, Joong Goo
(author)
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Kang, Chul Hoo
(author)
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Kwon, Jee HyunUniversity of Ulsan
(author)
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Kim, Wook JooUniversity of Ulsan
(author)
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Shin, Dong Ick
(author)
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Yum, Kyu Sun
(author)
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Sohn, Sung Il
(author)
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Hong, Jeong Ho
(author)
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Park, Hyungjong
(author)
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Kim, ChulhoHallym University
(author)
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Lee, Sang HwaHallym University
(author)
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Lee, Juneyoung
(author)
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Gorelick, Philip B.Northwestern University Feinberg School of Medicine
(author)
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Norrving, BoLund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research,Skåne University Hospital(Swepub:lu)neur-bno
(author)
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Bae, Hee JoonSeoul National University
(author)
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Chonnam National UniversitySeoul National University
(creator_code:org_t)
Related titles
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In:International Journal of Stroke: SAGE Publications18:8, s. 1015-10201747-49301747-4949
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Kim, Joon Tae
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Kang, Jihoon
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Kim, Beom Joon
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Kim, Jun Yup
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Han, Moon Ku
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Cho, Ki Hyun
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Park, Man Seok
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Choi, Kang Ho
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Park, Jong Moo
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Kang, Kyusik
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Kim, Yong Soo
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Lee, Soo Joo
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Kim, Jae Guk
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Cha, Jae Kwan
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Kim, Dae Hyun
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Park, Tai Hwan
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Park, Sang Soon
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Choi, Jin Kyo
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Lee, Kyungbok
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Park, Kwang Yeol
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Jeong, Hae Bong
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Lee, Jun
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Kwon, Doo Hyuk
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Cho, Yong Jin
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Hong, Keun Sik
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Park, Hong Kyun
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Lee, Byung Chul
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Yu, Kyung Ho
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Oh, Mi Sun
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Lee, Minwoo
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Kim, Dong Eog
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Gwak, Dong Seok
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Choi, Jay Chol
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Kim, Joong Goo
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Kang, Chul Hoo
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Kwon, Jee Hyun
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Kim, Wook Joo
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Shin, Dong Ick
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Yum, Kyu Sun
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Sohn, Sung Il
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Hong, Jeong Ho
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Park, Hyungjong
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Kim, Chulho
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Lee, Sang Hwa
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Lee, Juneyoung
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Gorelick, Philip ...
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Norrving, Bo
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Bae, Hee Joon
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