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Association of 25-h...
Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men
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Lee, David M. (author)
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Vanderschueren, Dirk (author)
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Boonen, Steven (author)
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O'Neill, Terence W. (author)
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Pendleton, Neil (author)
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Pye, Stephen R. (author)
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Ravindrarajah, Rathi (author)
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Gielen, Evelien (author)
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Claessens, Frank (author)
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Bartfai, Gyoergy (author)
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Casanueva, Felipe F. (author)
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Finn, Joseph D. (author)
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Forti, Gianni (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, Thang S. (author)
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Huhtaniemi, Ilpo T. (author)
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Kula, Krzysztof (author)
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Lean, Michael E. J. (author)
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Punab, Margus (author)
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Wu, Frederick C. W. (author)
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(creator_code:org_t)
- 2013-12-26
- 2014
- English.
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In: Age and Ageing. - : Oxford University Press (OUP). - 1468-2834 .- 0002-0729. ; 43:4, s. 528-535
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Abstract
Subject headings
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- Setting: prospective cohort analysis within the European Male Ageing Study. Participants: 2,816 community-dwelling men aged 40-79 years at baseline. Methods: Cox regression was used to examine the association of all-cause mortality with 25(OH)D, 1,25(OH)(2)D and PTH; cardiovascular and cancer mortality were modelled using competing-risks regression. Results were expressed as hazard ratios (HR) and 95% confidence intervals (CIs) for Cox models; sub-hazard ratios (SHR) and 95% CIs for competing-risks models. Results: a total of 187 men died during a median of 4.3 years of follow-up. Serum levels of 25(OH)D (per 1 SD decrease: HR = 1.45; 95% CI = 1.16, 1.81) and 1,25(OH)(2)D (per 1 SD decrease: HR = 1.20; 95% CI = 1.00, 1.44) were associated with an increased risk of all-cause mortality after adjusting for age, centre, smoking, self-reported morbidities, physical activity and functional performance. Only levels of 25(OH)D < 25 nmol/l predicted cancer mortality (SHR = 3.33; 95% CI = 1.38, 8.04). Conclusion: lower 25(OH)D and 1,25(OH)(2)D levels independently predicted all-cause mortality in middle-aged and older European men. Associations with cancer mortality were only observed among men with very low levels of 25(OH)D. These associations were only partially explained by the range of adverse health and lifestyle factors measured here.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- 25-dihydroxyvitamin D
- 1
- parathyroid hormone
- mortality
- population based
- older people
- 25-hydroxyvitamin D
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lee, David M.
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Vanderschueren, ...
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Boonen, Steven
-
O'Neill, Terence ...
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Pendleton, Neil
-
Pye, Stephen R.
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show more...
-
Ravindrarajah, R ...
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Gielen, Evelien
-
Claessens, Frank
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Bartfai, Gyoergy
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Casanueva, Felip ...
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Finn, Joseph D.
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S.
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E. ...
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Punab, Margus
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Wu, Frederick C. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Age and Ageing
- By the university
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Lund University