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Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men

Lee, David M. (author)
Vanderschueren, Dirk (author)
Boonen, Steven (author)
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O'Neill, Terence W. (author)
Pendleton, Neil (author)
Pye, Stephen R. (author)
Ravindrarajah, Rathi (author)
Gielen, Evelien (author)
Claessens, Frank (author)
Bartfai, Gyoergy (author)
Casanueva, Felipe F. (author)
Finn, Joseph D. (author)
Forti, Gianni (author)
Giwercman, Aleksander (author)
Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
Han, Thang S. (author)
Huhtaniemi, Ilpo T. (author)
Kula, Krzysztof (author)
Lean, Michael E. J. (author)
Punab, Margus (author)
Wu, Frederick C. W. (author)
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 (creator_code:org_t)
2013-12-26
2014
English.
In: Age and Ageing. - : Oxford University Press (OUP). - 1468-2834 .- 0002-0729. ; 43:4, s. 528-535
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Setting: prospective cohort analysis within the European Male Ageing Study. Participants: 2,816 community-dwelling men aged 40-79 years at baseline. Methods: Cox regression was used to examine the association of all-cause mortality with 25(OH)D, 1,25(OH)(2)D and PTH; cardiovascular and cancer mortality were modelled using competing-risks regression. Results were expressed as hazard ratios (HR) and 95% confidence intervals (CIs) for Cox models; sub-hazard ratios (SHR) and 95% CIs for competing-risks models. Results: a total of 187 men died during a median of 4.3 years of follow-up. Serum levels of 25(OH)D (per 1 SD decrease: HR = 1.45; 95% CI = 1.16, 1.81) and 1,25(OH)(2)D (per 1 SD decrease: HR = 1.20; 95% CI = 1.00, 1.44) were associated with an increased risk of all-cause mortality after adjusting for age, centre, smoking, self-reported morbidities, physical activity and functional performance. Only levels of 25(OH)D < 25 nmol/l predicted cancer mortality (SHR = 3.33; 95% CI = 1.38, 8.04). Conclusion: lower 25(OH)D and 1,25(OH)(2)D levels independently predicted all-cause mortality in middle-aged and older European men. Associations with cancer mortality were only observed among men with very low levels of 25(OH)D. These associations were only partially explained by the range of adverse health and lifestyle factors measured here.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Keyword

25-dihydroxyvitamin D
1
parathyroid hormone
mortality
population based
older people
25-hydroxyvitamin D

Publication and Content Type

art (subject category)
ref (subject category)

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