onr:"swepub:oai:lup.lub.lu.se:1be98e7d-01d0-40eb-870e-793f2bfda379"
Search: onr:"swepub:oai:lup.lub.lu.se:1be98e7d-01d0-40eb-870e-793f2bfda379" > 5 ' flanking varian...
- 1 of 1
- Previous record
- Next record
- To hitlist
5 ' flanking variants of resistin are associated with obesity
- Engert, JC (author)
- Vohl, MC (author)
- Williams, SM (author)
- show more...
- Lepage, P (author)
- Loredo-Osti, JC (author)
- Faith, J (author)
- Dore, C (author)
- Renaud, Y (author)
- Burtt, NP (author)
- Villeneuve, A (author)
- Hirschhorn, JN (author)
- Altshuler, D (author)
- Despres, JP (author)
- Gaudet, D (author)
- Hudson, TJ (author)
- show less...
- (creator_code:org_t)
- American Diabetes Association, 2002
- 2002
- English.
- In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 51:5, s. 1629-1634
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Engert, JC
- Vohl, MC
- Williams, SM
- Lepage, P
- Loredo-Osti, JC
- Faith, J
- show more...
- Dore, C
- Renaud, Y
- Burtt, NP
- Villeneuve, A
- Hirschhorn, JN
- Altshuler, D
- Groop, Leif
- Despres, JP
- Gaudet, D
- Hudson, TJ
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Diabetes
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
