SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:1c57f93a-c6c2-4d69-a555-b6fb2bcf7d00"
 

Search: onr:"swepub:oai:lup.lub.lu.se:1c57f93a-c6c2-4d69-a555-b6fb2bcf7d00" > Accuracy of advance...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Schlegel, Todd T. (author)

Accuracy of advanced versus strictly conventional 12-lead ECG for detection and screening of coronary artery disease, left ventricular hypertrophy and left ventricular systolic dysfunction

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-06-16
  • Springer Science and Business Media LLC,2010

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1c57f93a-c6c2-4d69-a555-b6fb2bcf7d00
  • https://lup.lub.lu.se/record/1657662URI
  • https://doi.org/10.1186/1471-2261-10-28DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Resting conventional 12-lead ECG has low sensitivity for detection of coronary artery disease (CAD) and left ventricular hypertrophy (LVH) and low positive predictive value (PPV) for prediction of left ventricular systolic dysfunction (LVSD). We hypothesized that a similar to 5-min resting 12-lead advanced ECG test ("A-ECG") that combined results from both the advanced and conventional ECG could more accurately screen for these conditions than strictly conventional ECG. Methods: Results from nearly every conventional and advanced resting ECG parameter known from the literature to have diagnostic or predictive value were first retrospectively evaluated in 418 healthy controls and 290 patients with imaging-proven CAD, LVH and/or LVSD. Each ECG parameter was examined for potential inclusion within multi-parameter A-ECG scores derived from multivariate regression models that were designed to optimally screen for disease in general or LVSD in particular. The performance of the best retrospectively-validated A-ECG scores was then compared against that of optimized pooled criteria from the strictly conventional ECG in a test set of 315 additional individuals. Results: Compared to optimized pooled criteria from the strictly conventional ECG, a 7-parameter A-ECG score validated in the training set increased the sensitivity of resting ECG for identifying disease in the test set from 78% (72-84%) to 92% (88-96%) (P < 0.0001) while also increasing specificity from 85% (77-91%) to 94% (88-98%) (P < 0.05). In diseased patients, another 5-parameter A-ECG score increased the PPV of ECG for LVSD from 53% (41-65%) to 92% (78-98%) (P < 0.0001) without compromising related negative predictive value. Conclusion: Resting 12-lead A-ECG scoring is more accurate than strictly conventional ECG in screening for CAD, LVH and LVSD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kulecz, Walter B. (author)
  • Feiveson, Alan H. (author)
  • Greco, E. Carl (author)
  • DePalma, Jude L. (author)
  • Starc, Vito (author)
  • Vrtovec, Bojan (author)
  • Rahman, M. Atiar (author)
  • Bungo, Michael W. (author)
  • Hayat, Matthew J. (author)
  • Bauch, Terry (author)
  • Delgado, Reynolds (author)
  • Warren, Stafford G. (author)
  • Nunez-Medina, Tulio (author)
  • Medina, Ruben (author)
  • Jugo, Diego (author)
  • Arheden, HåkanLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)klfy-har (author)
  • Pahlm, OlleLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)klfy-opa (author)
  • Klinisk fysiologi, LundSektion V (creator_code:org_t)

Related titles

  • In:BMC Cardiovascular Disorders: Springer Science and Business Media LLC101471-2261

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view