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Search: onr:"swepub:oai:lup.lub.lu.se:1ca62aba-0c4a-46c1-baca-2cab4b0edac0" > The Impact of Quadr...

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  • Brown, Darron R. (author)

The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Generally HPV-Naive Women Aged 16-26 Years

  • Article/chapterEnglish2009

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  • Oxford University Press (OUP),2009

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  • LIBRIS-ID:oai:lup.lub.lu.se:1ca62aba-0c4a-46c1-baca-2cab4b0edac0
  • https://lup.lub.lu.se/record/1404704URI
  • https://doi.org/10.1086/597307DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118429423URI

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  • Language:English
  • Summary in:English

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  • Subject category:kon swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Background. Human papillomavirus (HPV)-6/11/16/18 vaccine reduces the risk of HPV-6/11/16/18-related cervical intraepithelial neoplasia (CIN) 1-3 or adenocarcinoma in situ (AIS). Here, its impact on CIN1-3/AIS associated with nonvaccine oncogenic HPV types was evaluated. Methods. We enrolled 17,622 women aged 16-26 years. All underwent cervicovaginal sampling and Pap testing at regular intervals for up to 4 years. HPV genotying was performed for biopsy samples, and histological diagnoses were determined by a pathology panel. Analyses were conducted among subjects who were negative for 14 HPV types on day 1. Prespecified analyses included infection of >= 6 months' duration and CIN1-3/AIS due to the 2 and 5 most common HPV types in cervical cancer after HPV types 16 and 18, as well as all tested nonvaccine types. Results. Vaccination reduced the incidence of HPV-31/45 infection by 40.3% (95% confidence interval [CI], 13.9% to 59.0%) and of CIN1-3/AIS by 43.6% (95% CI, 12.9% to 64.1%), respectively. The reduction in HPV-31/33/45/52/58 infection and CIN1-3/AIS was 25.0% (95% CI, 5.0% to 40.9%) and 29.2% (95% CI, 8.3% to 45.5%), respectively. Efficacy for CIN2-3/AIS associated with the 10 nonvaccine HPV types was 32.5% (95% CI, 6.0% to 51.9%). Reductions were most notable for HPV-31. Conclusions. HPV-6/11/16/18 vaccine reduced the risk of CIN2-3/AIS associated with nonvaccine types responsible for similar to 20% of cervical cancers. The clinical benefit of cross-protection is not expected to be fully additive to the efficacy already observed against HPV-6/11/16/18-related disease, because women may have >1 CIN lesion, each associated with a different HPV type.

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  • Kjaer, Susanne K. (author)
  • Sigurdsson, Kristjan (author)
  • Iversen, Ole-Erik (author)
  • Hernandez-Avila, Mauricio (author)
  • Wheeler, Cosette M. (author)
  • Perez, Gonzalo (author)
  • Koutsky, Laura A. (author)
  • Tay, Eng Hseon (author)
  • Garcia, Patricia (author)
  • Ault, Kevin A. (author)
  • Garland, Suzanne M. (author)
  • Leodolter, Sepp (author)
  • Olsson, Sven-EricKarolinska Institutet (author)
  • Tang, Grace W. K. (author)
  • Ferris, Daron G. (author)
  • Paavonen, Jorma (author)
  • Steben, Marc (author)
  • Bosch, F. Xavier (author)
  • Dillner, JoakimKarolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-jdi (author)
  • Joura, Elmar A. (author)
  • Kurman, Robert J. (author)
  • Majewski, Slawomir (author)
  • Munoz, Nubia (author)
  • Myers, Evan R. (author)
  • Villa, Luisa L. (author)
  • Taddeo, Frank J. (author)
  • Roberts, Christine (author)
  • Tadesse, Amha (author)
  • Bryan, Janine (author)
  • Lupinacci, Lisa C. (author)
  • Giacoletti, Katherine E. D. (author)
  • Sings, Heather L. (author)
  • James, Margaret (author)
  • Hesley, Teresa M. (author)
  • Barra, Eliav (author)
  • Karolinska InstitutetKlinisk mikrobiologi, Malmö (creator_code:org_t)

Related titles

  • In:Journal Of Infectious Diseases: Oxford University Press (OUP)199:7, s. 926-9350022-18991537-6613

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