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Occurrence of comor...
Occurrence of comorbidity following osteoarthritis diagnosis : a cohort study in the Netherlands
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- Kamps, A. (author)
- Erasmus University Medical Center
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- Runhaar, J. (author)
- Erasmus University Medical Center
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- de Ridder, M. A.J. (author)
- Erasmus University Medical Center
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- de Wilde, M. (author)
- Erasmus University Medical Center
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- van der Lei, J. (author)
- Erasmus University Medical Center
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- Zhang, W. (author)
- University of Nottingham
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- Prieto-Alhambra, D. (author)
- University of Oxford,Erasmus University Medical Center
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- Englund, M. (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- de Schepper, E. I.T. (author)
- Erasmus University Medical Center
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- Bierma-Zeinstra, S. M.A. (author)
- Erasmus University Medical Center
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Osteoarthritis and Cartilage. - : Elsevier BV. - 1063-4584. ; 31:4, s. 519-528
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Abstract
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- Objective: To determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA). Design: A cohort study was conducted using the Integrated Primary Care Information database, containing electronic health records of 2.5 million patients from the Netherlands. Adults at risk for OA were included. Diagnosis of knee or hip OA (=exposure) and 58 long-term comorbidities (=outcome) were defined by diagnostic codes following the International Classification of Primary Care coding system. Time between the start of follow-up and incident diagnosis of OA was defined as unexposed, and between diagnosis of OA and the end of follow-up as exposed. Age and sex adjusted hazard ratios (HRs) comparing comorbidity rates in exposed and unexposed patient time were estimated with 99.9% confidence intervals (CI). Results: The study population consisted of 1,890,712 patients. For 30 of the 58 studied comorbidities, exposure to knee OA showed a HR larger than 1. Largest positive associations (HR with (99.9% CIs)) were found for obesity 2.55 (2.29–2.84) and fibromyalgia 2.06 (1.53–2.77). For two conditions a HR < 1 was found, other comorbidities showed no association with exposure to knee OA. For 26 comorbidities, exposure to hip OA showed a HR larger than 1. The largest were found for polymyalgia rheumatica 1.81 (1.41–2.32) and fibromyalgia 1.70 (1.10–2.63). All other comorbidities showed no associations with hip OA. Conclusion: This study showed that many comorbidities were diagnosed more often in patients with knee or hip OA. This suggests that the management of OA should consider the risk of other long-term-conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Comorbidity
- Electronic health record (EHR)
- Osteoarthritis
- Primary care
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kamps, A.
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Runhaar, J.
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de Ridder, M. A. ...
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de Wilde, M.
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van der Lei, J.
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Zhang, W.
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show more...
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Prieto-Alhambra, ...
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Englund, M.
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de Schepper, E. ...
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Bierma-Zeinstra, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Osteoarthritis a ...
- By the university
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Lund University