Search: onr:"swepub:oai:lup.lub.lu.se:1da59786-8302-4fd8-a4cd-a950f8864152" > Fimbriae reprogram ...
Fältnamn | Indikatorer | Metadata |
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000 | 05791naa a2200421 4500 | |
001 | oai:lup.lub.lu.se:1da59786-8302-4fd8-a4cd-a950f8864152 | |
003 | SwePub | |
008 | 190614s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/1da59786-8302-4fd8-a4cd-a950f88641522 URI |
024 | 7 | a https://doi.org/10.1371/journal.ppat.10076712 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ambite, Inesu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancerinfektion,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Cancer Infection,Lund University Research Groups4 aut0 (Swepub:lu)med-iam |
245 | 1 0 | a Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae |
264 | c 2019-06-10 | |
264 | 1 | b Public Library of Science (PLoS),c 2019 |
520 | a Pathogens rely on a complex virulence gene repertoire to successfully attack their hosts. We were therefore surprised to find that a single fimbrial gene reconstitution can return the virulence-attenuated commensal strain Escherichia coli 83972 to virulence, defined by a disease phenotype in human hosts. E. coli 83972pap stably reprogrammed host gene expression, by activating an acute pyelonephritis-associated, IRF7-dependent gene network. The PapG protein was internalized by human kidney cells and served as a transcriptional agonist of IRF-7, IFN-β and MYC, suggesting direct involvement of the fimbrial adhesin in this process. IRF-7 was further identified as a potent upstream regulator (-log (p-value) = 61), consistent with the effects in inoculated patients. In contrast, E. coli 83972fim transiently attenuated overall gene expression in human hosts, enhancing the effects of E. coli 83972. The inhibition of RNA processing and ribosomal assembly indicated a homeostatic rather than a pathogenic end-point. In parallel, the expression of specific ion channels and neuropeptide gene networks was transiently enhanced, in a FimH-dependent manner. The studies were performed to establish protective asymptomatic bacteriuria in human hosts and the reconstituted E. coli 83972 variants were developed to improve bacterial fitness for the human urinary tract. Unexpectedly, P fimbriae were able to drive a disease response, suggesting that like oncogene addiction in cancer, pathogens may be addicted to single super-virulence factors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
700 | 1 | a Butler, Daniel S Cu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancerinfektion,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Cancer Infection,Lund University Research Groups4 aut0 (Swepub:lu)da3085bu |
700 | 1 | a Stork, Christophu University of Münster4 aut |
700 | 1 | a Grönberg-Hernández, Jennyu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-jng |
700 | 1 | a Köves, Belau Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-bks |
700 | 1 | a Zdziarski, Jaroslawu Julius Maximilian University of Würzburg4 aut |
700 | 1 | a Pinkner, Jeromeu Washington University School of Medicine4 aut |
700 | 1 | a Hultgren, Scott Ju Washington University School of Medicine4 aut |
700 | 1 | a Dobrindt, Ulrichu Julius Maximilian University of Würzburg4 aut |
700 | 1 | a Wullt, Björnu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)uro-bwu |
700 | 1 | a Svanborg, Catharinau Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancerinfektion,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Cancer Infection,Lund University Research Groups4 aut0 (Swepub:lu)mmb-csv |
710 | 2 | a Avdelningen för mikrobiologi, immunologi och glykobiologi - MIGb Institutionen för laboratoriemedicin4 org |
773 | 0 | t PLoS Pathogensd : Public Library of Science (PLoS)g 15:6, s. 1007671-1007671q 15:6<1007671-1007671x 1553-7366x 1553-7374 |
856 | 4 | u http://dx.doi.org/10.1371/journal.ppat.1007671x freey FULLTEXT |
856 | 4 | u https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007671&type=printable |
856 | 4 8 | u https://lup.lub.lu.se/record/1da59786-8302-4fd8-a4cd-a950f8864152 |
856 | 4 8 | u https://doi.org/10.1371/journal.ppat.1007671 |
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