onr:"swepub:oai:lup.lub.lu.se:1ddfa1d5-b4c9-4fc1-8619-75649324bc9d"
Search: onr:"swepub:oai:lup.lub.lu.se:1ddfa1d5-b4c9-4fc1-8619-75649324bc9d" > Discordant xenograf...
- 1 of 1
- Previous record
- Next record
- To hitlist
Discordant xenografts : different outcome after mouse and rat neural tissue transplantation to guinea-pigs
-
- Larsson, L C (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
-
- Duan, W M (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
-
- Widner, H (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Regeneration in Movement Disorders,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
- (creator_code:org_t)
- 1999
- 1999
- English 10 s.
- In: Brain Research Bulletin. - 0361-9230. ; 49:5, s. 76-367
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Embryonic neural tissue obtained from other species has been considered as a donor tissue source in repair strategies for human neurodegenerative disorders. The neuro- and immunobiology of distantly related species combinations, discordant xenografts, need to be characterised. For this purpose, a small animal model would be an important research tool. Adult guinea-pigs, and adult rats as controls, received intrastriatal grafts of either mouse or rat embryonic ventral mesencephalic tissue. The survival rates and types of host immune response were assessed at 2 weeks after grafting using stereological techniques and semi-quantitative evaluations. In the mouse-to-guinea-pig group, all transplants were rejected and no tyrosine hydroxylase-immuno reactive (TH-IR) cells remained. In the rat-to-guinea-pig group, there was good survival of TH-IR cells (5050 SEM+/-1550), similar to that in the rat-to-rat group (4900 SEM+/-1540). In the mouse-to-rat group, half of the animals had no surviving TH-IR cells (520 SEM+/-230 for the whole group). These species combinations offer inexpensive, efficient, and suitable conditions to study important survival factors for discordant xenogeneic neural tissue transplants. The factors responsible for the divergent graft outcomes between the two combinations might provide clues on how to manipulate xenogeneic tissue to increase survival rates in the future.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Animals
- Astrocytes
- Complement System Proteins
- Corpus Striatum
- Female
- Fetal Tissue Transplantation
- Graft Survival
- Guinea Pigs
- Hemolysis
- Histocompatibility Antigens
- Immunoglobulins
- Macrophage-1 Antigen
- Mesencephalon
- Mice
- Microglia
- Rats
- Rats, Sprague-Dawley
- Transplantation, Heterologous
- Tyrosine 3-Monooxygenase
- Journal Article
- Research Support, Non-U.S. Gov't
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Brain Research Bulletin (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Larsson, L C
- Duan, W M
- Widner, H
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Brain Research B ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
