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Positive patch test...
Positive patch test reactions to oxidized limonene: exposure and relevance
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- Bråred Christensson, Johanna, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institutionen för kemi och molekylärbiologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,Department of Chemistry and Molecular Biology
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Andersen, Klaus E. (author)
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- Bruze, Magnus (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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Johansen, Jeanne D. (author)
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Garcia-Bravo, Begona (author)
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Gimenez Arnau, Ana (author)
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Goh, Chee-Leok (author)
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Nixon, Rosemary (author)
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White, Ian R. (author)
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(creator_code:org_t)
- 2014-08-07
- 2014
- English.
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In: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 71:5, s. 264-272
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Abstract
Subject headings
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- Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results. Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, >70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions. Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- allergic contact dermatitis
- autoxidation
- fragrance allergy
- hydroperoxide
- limonene
- oxidation products
- patch test
- relevance
- terpenes
Publication and Content Type
- art (subject category)
- ref (subject category)
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