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Association of infl...
Association of inflammatory mediators with frailty status in older adults : results from a systematic review and meta-analysis
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- Marcos-Pérez, Diego (author)
- Institute of Biomedical Research of A Coruña, INIBIC,University of A Coruña
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- Sánchez-Flores, María (author)
- University of Porto,National Health Institute Doutor Ricardo Jorge, Lisbon,University of A Coruña
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- Proietti, Stefania (author)
- IRCCS San Raffaele Pisana
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- Bonassi, Stefano (author)
- Vita-Salute San Raffaele University,IRCCS San Raffaele Pisana
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- Costa, Solange (author)
- University of Porto,National Health Institute Doutor Ricardo Jorge, Lisbon
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- Teixeira, Joao Paulo (author)
- National Health Institute Doutor Ricardo Jorge, Lisbon,University of Porto
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- Fernández-Tajes, Juan (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Wellcome Trust Centre for Human Genetics
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- Pásaro, Eduardo (author)
- University of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC
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- Laffon, Blanca (author)
- University of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC
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- Valdiglesias, Vanessa (author)
- University of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC,University of Porto
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(creator_code:org_t)
- 2020-08-15
- 2020
- English 23 s.
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In: GeroScience. - : Springer Science and Business Media LLC. - 2509-2715 .- 2509-2723. ; 42:6, s. 1451-1473
- Related links:
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. “Inflammaging”, an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive protein (CRP), interleukin 6 (IL6), and tumor necrosis factor α. To reduce heterogeneity, meta-analyses were restricted to studies identifying frailty by the Fried et al. [1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146–56] phenotypic criteria. Quantitative analyses measuring the association between frailty and biomarker concentrations showed significant differences when frail subjects were compared to non-frail and pre-frail subjects for CRP and IL6. This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- C-reactive protein
- Frailty
- Inflammaging
- Interleukin 6
- Older adults
- Tumor necrosis factor alpha
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- for (subject category)
- ref (subject category)
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Marcos-Pérez, Di ...
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Sánchez-Flores, ...
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Proietti, Stefan ...
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Bonassi, Stefano
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Costa, Solange
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Teixeira, Joao P ...
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Fernández-Tajes, ...
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Pásaro, Eduardo
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Laffon, Blanca
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Valdiglesias, Va ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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GeroScience
- By the university
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Lund University