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Proteomics-protein profiling technology: the trend towards a microfabricated toolbox concept
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- Laurell, Thomas (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
- Nilsson, J. (author)
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- Marko-Varga, György (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
- (creator_code:org_t)
- Elsevier BV, 2001
- 2001
- English.
- In: Trac. Trends in Analytical Chemistry. - : Elsevier BV. - 0165-9936. ; 20:5, s. 225-231
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The use of mono-crystalline silicon microstructures for high-speed and high sensitivity protein mapping and protein identification is presented as an important contribution within the field of proteomics. The various approaches for handling minute amounts of protein sample are described. Piezoelectric dispensing units developed in-house are being used for sample-handling and the generation of 60-pl droplets, interfacing with high-density microchip MALDI-TOF MS target plates having an array density of 4000 nanovials/square inch. Examples of applications to microtechnology, and future trends in our research are outlined. (C) 2001 Elsevier Science B.V. All rights reserved.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
Keyword
- proteomics
- microtechnology
- mass spectrometry
- piezoelectric
- dispensing
- nanovial
- FLIGHT MASS-SPECTROMETRY
- SAMPLE PREPARATION
- LASER
- MICRODISSECTION
- CHROMATOGRAPHY
- SEPARATIONS
- SYSTEMS
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- art (subject category)
- ref (subject category)
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