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Changes in bleeding...
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Holm, ElenaLund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups
(author)
Changes in bleeding patterns in von Willebrand disease after institution of long-term replacement therapy: results from the von Willebrand Disease Prophylaxis Network.
- Article/chapterEnglish2015
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LIBRIS-ID:oai:lup.lub.lu.se:209ee6e2-c7d9-4bcc-b90c-f4a094a43c1a
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https://lup.lub.lu.se/record/5143485URI
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https://doi.org/10.1097/MBC.0000000000000257DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Clinically, the leading symptom in von Willebrand disease (VWD) is bleeding, chiefly of mucosal type, for example, epistaxis, gingival, or gastrointestinal bleeding, and menorrhagia. In severe forms of VWD with secondary deficiency of factor VIII, spontaneous joint bleeding, resembling that observed in severe haemophilia A, may also be observed. The bleeding patterns of VWD can affect quality of life, and may be life-threatening. The von Willebrand Disease Prophylaxis Network is an international study group formed with the goal of investigating the role of prophylaxis in clinically severe VWD. The objective of the present study is to investigate the response to prophylaxis focusing primarily on epistaxis, joint bleeding, gastrointestinal bleeding, and heavy bleeding associated with menses. Data from 105 subjects, 10 enrolled in a prospective study and 95 in a retrospective study between 2008 and 2013, were available for analysis. The median annualized rate reductions in bleeding were significant for epistaxis (P < 0.0001), gastrointestinal bleeding (P = 0.0003), joint bleeding (P < 0.0001), and menorrhagia (P = 0.008). Doses on a group level were approximately the same prior to and during prophylaxis, but more patients with gastrointestinal bleeding had prophylaxis three or more times per week as well as higher dosages. Our study, which primarily used retrospective data, indicates that prospective studies are needed to better delineate the doses and dose intervals that should be used for prophylactic treatment of VWD.
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Abshire, Thomas C
(author)
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Bowen, Joel
(author)
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Álvarez, M A Teresa
(author)
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Bolton-Maggs, Paula
(author)
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Carcao, Manuel
(author)
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Federici, Augusto B
(author)
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Gill, Joan Cox
(author)
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Halimeh, Susan
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Kempton, Christine
(author)
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Key, Nigel S
(author)
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Kouides, Peter
(author)
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Lail, Alice
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Landorph, Andrea
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Leebeek, Frank
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Makris, Michael
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Mannucci, Pier
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Mauser-Bunschoten, Eveline P
(author)
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Nugent, Diane
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Valentino, Leonard A
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Winikoff, Rochelle
(author)
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Berntorp, ErikLund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups(Swepub:lu)medf-ebe
(author)
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Klinisk koagulationsmedicin, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Blood Coagulation and Fibrinolysis26:4, s. 383-3881473-5733
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Holm, Elena
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Abshire, Thomas ...
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Bowen, Joel
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Álvarez, M A Ter ...
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Bolton-Maggs, Pa ...
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Carcao, Manuel
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Federici, August ...
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Gill, Joan Cox
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Halimeh, Susan
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Kempton, Christi ...
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Key, Nigel S
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Kouides, Peter
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Lail, Alice
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Landorph, Andrea
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Leebeek, Frank
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Makris, Michael
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Mannucci, Pier
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Mauser-Bunschote ...
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Nugent, Diane
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Valentino, Leona ...
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Winikoff, Rochel ...
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Berntorp, Erik
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Hematology
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Blood Coagulatio ...
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Lund University