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Spinal NMDA-recepto...
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Kalliomäki, Jarkko
(author)
Spinal NMDA-receptor dependent amplification of nociceptive transmission to rat primary somatosensory cortex (SI).
- Article/chapterEnglish2003
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LIBRIS-ID:oai:lup.lub.lu.se:20f4d8e8-b8f6-4f1f-af9b-968f4a449493
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https://lup.lub.lu.se/record/116665URI
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https://doi.org/10.1016/S0304-3959(03)00002-2DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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The role of NMDA mechanisms in spinal pathways mediating acute nociceptive input to the somatosensory cortex is not clear. In this study, the effect of NMDA-antagonists on nociceptive C fibre transmission to the primary somatosensory cortex (SI) was investigated. Cortical field potentials evoked by CO2-laser stimulation of the skin were recorded in the halothane/nitrous oxide anaesthetized rat. The SI nociceptive evoked potential (EP) amplitudes were dependent on the frequency of noxious heat stimulation. The amplitudes of SI potentials evoked by CO2-laser pulses (duration 15–20 ms, stimulation energy 21–28 mJ/mm2) delivered at a frequency of 0.1 Hz were approximately 40% of the amplitudes of potentials evoked by 1.0 Hz stimulation. After intrathecal lumbar application of either of the NMDA-antagonists CPP or MK-801, the amplitudes of nociceptive SI potentials, evoked by 1.0 Hz stimulation of the contralateral hindpaw, were reduced to approximately 40% of controls. By contrast, field potentials evoked by 0.1 Hz stimulation of the hindpaw were unaffected by MK-801. SI potentials evoked by 1.0 Hz stimulation of the contralateral forepaw did not change after lumbar application of CPP or MK-801, indicating that the depression of hindpaw EPs was due to a segmental effect in the spinal cord. It is concluded that spinal NMDA-receptor mechanisms amplify the acute transmission of nociceptive C fiber input to SI in a frequency-dependent way.
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Granmo, MarcusLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups(Swepub:lu)mphy-mgr
(author)
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Schouenborg, JensLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups(Swepub:lu)mphy-jsc
(author)
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NeurofysiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Pain104:1-2, s. 195-2001872-6623
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