Hormonal regulation of beta(2)-adrenergic receptor level in prostate cancer

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Ramberg, Hakon (author)

Hormonal regulation of beta(2)-adrenergic receptor level in prostate cancer

Article/chapterEnglish2008

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2008
Wiley,2008

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LIBRIS-ID:oai:lup.lub.lu.se:212149a5-7977-4914-a83c-b39844c9b9a4
https://lup.lub.lu.se/record/1187319URI
https://doi.org/10.1002/pros.20778DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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BACKGROUND. Androgen deprivation is the only effective systemic therapy available for patients with prostatic carcinoma, but is associated with a gradual transition to a hormone-refractory prostate cancer (HRCAP) in which ligand-independent activation of the androgen receptor has been implicated. The beta(2)-adrenergic receptor (beta(2)-AR) is a well-known activator of the androgen receptor. METHODS. Prostatic cell lines were analyzed using cDNA micro-array, real time RT-PCR, radioligand binding assay, cAMP measurements, transfection and thymidine incorporation assay. Clinical specimens were studied by immunohistochemistry and Affymetrix microarrays. RESULTS. Here, we show that beta(2)-AR was transiently down-regulated both at mRNA- and protein levels when hormone-sensitive prostate cancer cells, LNCaP, were cultured in steroid stripped medium (charcoal-stripped fetal calf serum) or when the cells were treated with the anti-androgen, bicalutamide (Casodex). The number of beta-adrenergic receptors was modestly up-regulated in androgen independent cell lines (LNCaP-C4, LNCaP-C4-2 and DU145) compared to LNCaP. Triiodothyronine (T3) increased the level of beta(2)-AR and the effect of T3 was inhibited by bicalutamide. Immunohistochemical staining of human prostate specimens showed high expression of beta(2)-AR in glandular, epithelial cells and increased expression in malignant cells compared to benign hyperplasia and normal tissue. Interestingly, beta(2)-AR mRNA was strongly down-regulated by androgen ablation therapy of prostate cancer patients. CONCLUSION. The level of beta(2)-AR was increased by T3 in prostatic adenocarcinoma cells and reduced in prostate cancer patients who had received androgen ablation therapy for 3 months.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
triiodothyronine
bicalutamide
LNCaP cells

Added entries (persons, corporate bodies, meetings, titles ...)

Eide, Turid (author)
Krobert, Kurt Allen (author)
Levy, Finn Olav (author)
Dizeyi, NishtmanLund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups(Swepub:lu)kir-dni (author)
Bjartell, AndersLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups(Swepub:lu)kir-abj (author)
Abrahamsson, Per-AndersLund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups(Swepub:lu)uro-paa (author)
Tasken, Kristin Austlid (author)
Urologi, Malmö (Abrahamsson)Forskargrupper vid Lunds universitet (creator_code:org_t)

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In:The Prostate: Wiley68:10, s. 1133-11420270-41371097-0045

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By the author/editor: Ramberg, Hakon; Eide, Turid; Krobert, Kurt Al ...; Levy, Finn Olav; Dizeyi, Nishtman; Bjartell, Anders; show more...; Abrahamsson, Per ...; Tasken, Kristin ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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