Search: onr:"swepub:oai:lup.lub.lu.se:2138e8c3-bbf6-42d8-9a61-61990dd32fe9" >
Prognostic Signific...
-
Tana, ClaudioSs Annunziata Hospital
(author)
Prognostic Significance of Chest Imaging by LUS and CT in COVID-19 Inpatients : The ECOVID Multicenter Study
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2021-08-31
-
S. Karger AG,2022
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:2138e8c3-bbf6-42d8-9a61-61990dd32fe9
-
https://lup.lub.lu.se/record/2138e8c3-bbf6-42d8-9a61-61990dd32fe9URI
-
https://doi.org/10.1159/000518516DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background: Point-of-care lung ultrasound (LUS) score is a semiquantitative score of lung damage severity. High-resolution computed tomography (HRCT) is the gold standard method to evaluate the severity of lung involvement from the novel coronavirus disease (COVID-19). Few studies have investigated the clinical significance of LUS and HRCT scores in patients with COVID-19. Therefore, the aim of this study was to evaluate the prognostic yield of LUS and of HRCT in COVID-19 patients. Methods: We carried out a multicenter, retrospective study aimed at evaluating the prognostic yield of LUS and HRCT by exploring the survival curve of COVID-19 inpatients. LUS and chest CT scores were calculated retrospectively by 2 radiologists with >10 years of experience in chest imaging, and the decisions were reached in consensus. LUS score was calculated on the basis of the presence or not of pleural line abnormalities, B-lines, and lung consolidations. The total score (range 0-36) was obtained from the sum of the highest scores obtained in each region. CT score was calculated for each of the 5 lobes considering the anatomical extension according to the percentage parenchymal involvement. The resulting overall global semiquantitative CT score was the sum of each single lobar score and ranged from 0 (no involvement) to 25 (maximum involvement). Results: One hundred fifty-three COVID-19 inpatients (mean age 65 ± 15 years; 65% M), including 23 (15%) in-hospital deaths for any cause over a mean follow-up of 14 days were included. Mean LUS and CT scores were 19 ± 12 and 10 ± 7, respectively. A strong positive linear correlation between LUS and CT scores (Pearson correlation r = 0.754; R = 0.568; p < 0.001) was observed. By ROC curve analysis, the optimal cut-point for mortality prediction was 20 for LUS score and 4.5 for chest CT score. According to Kaplan-Meier survival analysis, in-hospital mortality significantly increased among COVID-19 patients presenting with an LUS score ≥20 (log-rank 0.003; HR 9.87, 95% CI: 2.22-43.83) or a chest CT score ≥4.5 (HR 4.34, 95% CI: 0.97-19.41). At multivariate Cox regression analysis, LUS score was the sole independent predictor of in-hospital mortality yielding an adjusted HR of 7.42 (95% CI: 1.59-34.5). Conclusion: LUS score is useful to stratify the risk in COVID-19 patients, predicting those that are at high risk of mortality.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ricci, FabrizioLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Casa di Cura Villa Serena di Città Sant'Angelo,University G.d'Annunzio of Chieti-Pescara(Swepub:lu)fa7062ri
(author)
-
Coppola, Maria GabriellaOspedale del Mare
(author)
-
Mantini, CesareUniversity G.d'Annunzio of Chieti-Pescara
(author)
-
Lauretani, FulvioParma University Hospital,University of Parma
(author)
-
Campanozzi, DanieleSan Salvatore Hospital
(author)
-
Renda, GiuliaUniversity G.d'Annunzio of Chieti-Pescara
(author)
-
Gallina, SabinaUniversity G.d'Annunzio of Chieti-Pescara
(author)
-
Lugará, MarinaOspedale del Mare
(author)
-
Cipollone, FrancescoUniversity G.d'Annunzio of Chieti-Pescara
(author)
-
Giamberardino, Maria AdeleUniversity G.d'Annunzio of Chieti-Pescara
(author)
-
Mucci, LucianoSan Salvatore Hospital
(author)
-
Ss Annunziata HospitalKardiovaskulär forskning - hypertoni
(creator_code:org_t)
Related titles
-
In:Respiration: S. Karger AG101:2, s. 122-1310025-79311423-0356
Internet link
Find in a library
To the university's database
- By the author/editor
-
Tana, Claudio
-
Ricci, Fabrizio
-
Coppola, Maria G ...
-
Mantini, Cesare
-
Lauretani, Fulvi ...
-
Campanozzi, Dani ...
-
show more...
-
Renda, Giulia
-
Gallina, Sabina
-
Lugará, Marina
-
Cipollone, Franc ...
-
Giamberardino, M ...
-
Mucci, Luciano
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Anesthesiology a ...
- Articles in the publication
-
Respiration
- By the university
-
Lund University