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- Krook-Magnuson, EstherUniversity of California System (author)
How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2014-05-14
- Dordrecht :Springer Netherlands,2014
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:218e2095-0a68-4597-a670-a83c11a58baa
- https://lup.lub.lu.se/record/4962505URI
- https://doi.org/10.1007/978-94-017-8914-1_26DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Recent technological advances open exciting avenues for improving the understanding of mechanisms in a broad range of epilepsies. This chapter focuses on the development of optogenetics and on-demand technologies for the study of epilepsy and the control of seizures. Optogenetics is a technique which, through cell-type selective expression of light-sensitive proteins called opsins, allows temporally precise control via light delivery of specific populations of neurons. Therefore, it is now possible not only to record interictal and ictal neuronal activity, but also to test causality and identify potential new therapeutic approaches. We first discuss the benefits and caveats to using optogenetic approaches and recent advances in optogenetics related tools. We then turn to the use of optogenetics, including on-demand optogenetics in the study of epilepsies, which highlights the powerful potential of optogenetics for epilepsy research.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- On-demand
- Responsive
- Channelrhodopsin
- Halorhodopsin
- Arch
- AAV
- Optrode
- Seizure
Added entries (persons, corporate bodies, meetings, titles ...)
- Ledri, MarcoLund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups,Skåne University Hospital,Hungarian Academy of Sciences(Swepub:lu)ma6384le (author)
- Soltesz, IvanUniversity of California System (author)
- Kokaia, MerabLund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)neur-mko (author)
- Scharfman, Helen E. (editor)
- Buckmaster, Paul S. (editor)
- University of California SystemExperimentell Epilepsi (creator_code:org_t)
Related titles
- In:Issues in Clinical Epileptology: A View From the BenchDordrecht : Springer Netherlands813, s. 319-3360065-25989789401789141
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