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After 6 years with Xolair; a 3-year withdrawal follow-up
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- Nopp, A. (author)
- Karolinska Institutet
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- Johansson, S. G. O. (author)
- Karolinska Institutet
- Adedoyin, J. (author)
- show more...
- Palmqvist, M. (author)
- Oman, H. (author)
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- (creator_code:org_t)
- Wiley, 2010
- 2010
- English.
- In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 65:1, s. 56-60
- Journal article (peer-reviewed)
Abstract
Subject headings
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- P>Background: This study reports the clinical and immunological state of patients 3 years after a 6-year period of Xolair treatment for severe allergic asthma. Methods: The patient's cat allergen sensitivity, measured as CD-sens, IgE and IgE- and IgG4 antibodies, was analysed and compared with asthma severity evaluated from FEV1 and a questionnaire. Results: Three years after treatment with Xolair was stopped, 12/18 patients reported improved or unchanged asthma compared with ongoing Xolair treatment. Most of the patients were in a stable clinical condition, 16/18 had not increased nightly asthma attacks and 14/18 little or no increase in medication. The CD-sens to cat was still significantly lower (P < 0.02) than untreated patients with allergic asthma and lower than expected from their serum IgE antibody levels. Conclusion: Most of the patients in this study had, still 3 years after closing of 6 years Xolair treatment, a surprisingly mild and stable asthma. Interestingly, the observed, considerable, downregulation of basophil allergen sensitivity, CD-sens, most likely representing mast cell allergen sensitivity, contributed to the clinical results.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- omalizumab
- CD-sens
- IgE antibody
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- art (subject category)
- ref (subject category)
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- Allergy
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- Lund University
- Karolinska Institutet
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