Search: onr:"swepub:oai:lup.lub.lu.se:227e0c06-4693-44cb-8e97-809669d8f8b6" >
Cerebrovascular Eve...
-
Hanly, John G.Dalhousie University
(author)
Cerebrovascular Events in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
- Article/chapterEnglish2018
Publisher, publication year, extent ...
-
2018-09-01
-
Wiley,2018
-
10 s.
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:227e0c06-4693-44cb-8e97-809669d8f8b6
-
https://lup.lub.lu.se/record/227e0c06-4693-44cb-8e97-809669d8f8b6URI
-
https://doi.org/10.1002/acr.23509DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:139259444URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal ischemia, 4) subarachnoid/intracranial hemorrhage, and 5) sinus thrombosis. Global disease activity (Systemic Lupus Erythematosus Disease [SLE] Activity Index 2000), damage scores (SLE International Collaborating Clinics/American College of Rheumatology Damage Index), and Short Form 36 (SF-36) scores were collected. Time to event, linear and logistic regressions, and multistate models were used as appropriate. Results: CerVEs were the fourth most frequent NP event: 82 of 1,826 patients had 109 events; of these events, 103 were attributed to SLE, and 44 were identified at the time of enrollment. The predominant events were stroke (60 of 109 patients) and transient ischemia (28 of 109 patients). CerVEs were associated with other NP events attributed to SLE, non–SLE-attributed NP events, African ancestry (at US SLICC sites), and increased organ damage scores. Lupus anticoagulant increased the risk of first stroke and sinus thrombosis and transient ischemic attack. Physician assessment indicated resolution or improvement in the majority of patients, but patients reported sustained reduction in SF-36 summary and subscale scores following a CerVE. Conclusion: CerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician-reported outcomes, patients reported a sustained reduction in health-related quality of life following a CerVE.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Li, QiujuUniversity of Cambridge
(author)
-
Su, LiUniversity of Cambridge
(author)
-
Urowitz, Murray B.University of Toronto
(author)
-
Gordon, CarolineUniversity of Birmingham
(author)
-
Bae, Sang CheolHanyang University
(author)
-
Romero-Diaz, JuanitaInstituto Nacional de Ciencias Médicas y Nutrición
(author)
-
Sanchez-Guerrero, JorgeUniversity of Toronto,Toronto Western Hospital
(author)
-
Bernatsky, SashaMcGill University
(author)
-
Clarke, Ann E.University of Calgary
(author)
-
Wallace, Daniel J.Cedars-Sinai Medical Center,University of California, Los Angeles
(author)
-
Isenberg, David A.University College London,New York University
(author)
-
Rahman, AnisurUniversity College London
(author)
-
Merrill, Joan T.Oklahoma Medical Research Foundation
(author)
-
Fortin, PaulCentre hospitalier universitaire de Québec
(author)
-
Gladman, Dafna D.University of Toronto,Toronto Western Hospital
(author)
-
Bruce, Ian N.Manchester University NHS Foundation Trust,University of Manchester
(author)
-
Petri, MichelleJohns Hopkins University
(author)
-
Ginzler, Ellen M.SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
(author)
-
Dooley, M. A.University of North Carolina
(author)
-
Steinsson, KristjanNational University Hospital of Iceland
(author)
-
Ramsey-Goldman, RosalindNorthwestern University
(author)
-
Zoma, Asad A.Hairmyres Hospital
(author)
-
Manzi, SusanAllegheny Health Network
(author)
-
Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni
(author)
-
Jonsen, AndreasLund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)reum-ajo
(author)
-
Khamashta, Munther A.King's College London,St Thomas' Hospital
(author)
-
Alarcón, Graciela S.University of Alabama
(author)
-
Chatham, WinnUniversity of Alabama
(author)
-
van Vollenhoven, Ronald F.Karolinska Institutet,Karolinska Institute
(author)
-
Aranow, CynthiaFeinstein Institute for Medical Research
(author)
-
Mackay, MegganFeinstein Institute for Medical Research
(author)
-
Ruiz-Irastorza, GuillermoGurutzeta/Cruces University Hospital,University of the Basque Country
(author)
-
Ramos-Casals, ManuelInstitutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona
(author)
-
Lim, S. SamEmory University
(author)
-
Inanc, MuratIstanbul University
(author)
-
Kalunian, Kenneth C.University of California, San Diego
(author)
-
Jacobsen, SorenCopenhagen University Hospital
(author)
-
Peschken, Christine A.University of Manitoba
(author)
-
Kamen, Diane L.Medical University of South Carolina
(author)
-
Askanase, AncaNew York University
(author)
-
Theriault, ChrisDalhousie University
(author)
-
Farewell, VernonUniversity of Cambridge
(author)
-
Dalhousie UniversityUniversity of Cambridge
(creator_code:org_t)
Related titles
-
In:Arthritis Care and Research: Wiley70:10, s. 1478-14872151-464X2151-4658
Internet link
Find in a library
To the university's database
- By the author/editor
-
Hanly, John G.
-
Li, Qiuju
-
Su, Li
-
Urowitz, Murray ...
-
Gordon, Caroline
-
Bae, Sang Cheol
-
show more...
-
Romero-Diaz, Jua ...
-
Sanchez-Guerrero ...
-
Bernatsky, Sasha
-
Clarke, Ann E.
-
Wallace, Daniel ...
-
Isenberg, David ...
-
Rahman, Anisur
-
Merrill, Joan T.
-
Fortin, Paul
-
Gladman, Dafna D ...
-
Bruce, Ian N.
-
Petri, Michelle
-
Ginzler, Ellen M ...
-
Dooley, M. A.
-
Steinsson, Krist ...
-
Ramsey-Goldman, ...
-
Zoma, Asad A.
-
Manzi, Susan
-
Nived, Ola
-
Jonsen, Andreas
-
Khamashta, Munth ...
-
Alarcón, Graciel ...
-
Chatham, Winn
-
van Vollenhoven, ...
-
Aranow, Cynthia
-
Mackay, Meggan
-
Ruiz-Irastorza, ...
-
Ramos-Casals, Ma ...
-
Lim, S. Sam
-
Inanc, Murat
-
Kalunian, Kennet ...
-
Jacobsen, Soren
-
Peschken, Christ ...
-
Kamen, Diane L.
-
Askanase, Anca
-
Theriault, Chris
-
Farewell, Vernon
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Arthritis Care a ...
- By the university
-
Lund University
-
Karolinska Institutet