A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results

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Pigot, HenryLund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: AI och digitalisering,LTH profilområden,LTH profilområde: Teknik för hälsa,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: AI and Digitalization,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,Faculty of Engineering, LTH (author)

A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results

Article/chapterEnglish2022

Publisher, publication year, extent ...

2022-05-20
Wiley,2022

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LIBRIS-ID:oai:lup.lub.lu.se:22e47e0e-5826-4a1a-b0d3-1ac86aec9a4c
https://lup.lub.lu.se/record/22e47e0e-5826-4a1a-b0d3-1ac86aec9a4cURI
https://doi.org/10.1111/aor.14307DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Background: Existing working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept designed to enable such control. Methods: Six ∼70 kg pig hearts were evaluated in vivo, then ex vivo in left-ventricular working mode using the presented afterload. Both in vivo and ex vivo, the hearts were evaluated at two exertion levels: at rest and following a 20 μg adrenaline bolus, while measuring aortic pressure and flow, left ventricular pressure and volume, and left atrial pressure. Results: The afterload gave aortic pressure waveforms that matched the general shape of the in vivo measurements. A wide range of physiological systolic pressures (93 to 160 mm Hg) and diastolic pressures (73 to 113 mm Hg) were generated by the afterload. Conclusions: With the presented afterload concept, multiple physiological loading conditions could be tested ex vivo, and compared with the corresponding in vivo data. An additional control loop from the set pressure limits to the measured systolic and diastolic aortic pressure is proposed to address discrepancies observed between the set limits and the measured pressures.

Subject headings and genre

TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk apparatteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering Medical Equipment Engineering hsv//eng
TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk laboratorie- och mätteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering Medical Laboratory and Measurements Technologies hsv//eng
cardiac afterload
ex vivo heart evaluation
functional evaluation
heart perfusion
heart transplantation
working heart

Added entries (persons, corporate bodies, meetings, titles ...)

Soltesz, KristianLund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)cont-kts (author)
Paskevicius, AudriusLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups(Swepub:lu)thor-apa (author)
Liao, QiumingLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups(Swepub:lu)thor-qli (author)
Sjöberg, TrygveLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)thor-tsj (author)
Steen, StigLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups(Swepub:lu)thor-sst (author)
Institutionen för reglerteknikInstitutioner vid LTH (creator_code:org_t)

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