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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05371naa a2200445 4500 | |
| 001 | oai:lup.lub.lu.se:22e47e0e-5826-4a1a-b0d3-1ac86aec9a4c | |
| 003 | SwePub | |
| 008 | 220825s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/22e47e0e-5826-4a1a-b0d3-1ac86aec9a4c2 URI |
| 024 | 7 | a https://doi.org/10.1111/aor.143072 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Pigot, Henryu Lund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: AI och digitalisering,LTH profilområden,LTH profilområde: Teknik för hälsa,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: AI and Digitalization,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,Faculty of Engineering, LTH4 aut0 (Swepub:lu)he6011pi |
| 245 | 1 0 | a A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results |
| 264 | c 2022-05-20 | |
| 264 | 1 | b Wiley,c 2022 |
| 520 | a Background: Existing working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept designed to enable such control. Methods: Six ∼70 kg pig hearts were evaluated in vivo, then ex vivo in left-ventricular working mode using the presented afterload. Both in vivo and ex vivo, the hearts were evaluated at two exertion levels: at rest and following a 20 μg adrenaline bolus, while measuring aortic pressure and flow, left ventricular pressure and volume, and left atrial pressure. Results: The afterload gave aortic pressure waveforms that matched the general shape of the in vivo measurements. A wide range of physiological systolic pressures (93 to 160 mm Hg) and diastolic pressures (73 to 113 mm Hg) were generated by the afterload. Conclusions: With the presented afterload concept, multiple physiological loading conditions could be tested ex vivo, and compared with the corresponding in vivo data. An additional control loop from the set pressure limits to the measured systolic and diastolic aortic pressure is proposed to address discrepancies observed between the set limits and the measured pressures. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk apparatteknik0 (SwePub)206042 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Equipment Engineering0 (SwePub)206042 hsv//eng |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk laboratorie- och mätteknik0 (SwePub)206012 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Laboratory and Measurements Technologies0 (SwePub)206012 hsv//eng |
| 653 | a cardiac afterload | |
| 653 | a ex vivo heart evaluation | |
| 653 | a functional evaluation | |
| 653 | a heart perfusion | |
| 653 | a heart transplantation | |
| 653 | a working heart | |
| 700 | 1 | a Soltesz, Kristianu Lund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)cont-kts |
| 700 | 1 | a Paskevicius, Audriusu Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups4 aut0 (Swepub:lu)thor-apa |
| 700 | 1 | a Liao, Qiumingu Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups4 aut0 (Swepub:lu)thor-qli |
| 700 | 1 | a Sjöberg, Trygveu Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)thor-tsj |
| 700 | 1 | a Steen, Stigu Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups4 aut0 (Swepub:lu)thor-sst |
| 710 | 2 | a Institutionen för reglerteknikb Institutioner vid LTH4 org |
| 773 | 0 | t Artificial Organsd : Wileyg 46:9, s. 1794-1803q 46:9<1794-1803x 0160-564Xx 1525-1594 |
| 856 | 4 | u http://dx.doi.org/10.1111/aor.14307x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/22e47e0e-5826-4a1a-b0d3-1ac86aec9a4c |
| 856 | 4 8 | u https://doi.org/10.1111/aor.14307 |
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