Search: onr:"swepub:oai:lup.lub.lu.se:2328cf15-8cd0-46dc-8105-444715833a28" > Severe lung lesions...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04060naa a2200469 4500 | |
001 | oai:lup.lub.lu.se:2328cf15-8cd0-46dc-8105-444715833a28 | |
003 | SwePub | |
008 | 160401s2000 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:1939957 | |
024 | 7 | a https://lup.lub.lu.se/record/11162362 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19399572 URI |
024 | 7 | a https://doi.org/10.1084/jem.192.10.14152 DOI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Persson, Kristinu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)medk-kpe |
245 | 1 0 | a Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system |
264 | 1 | b Rockefeller University Press,c 2000 |
520 | a Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected rats. These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
653 | a bradykinin | |
653 | a factor XII | |
653 | a high molecular weight kininogen | |
653 | a plasma kallikrein | |
653 | a protease inhibitor | |
700 | 1 | a Mörgelin, Matthiasu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-mmn |
700 | 1 | a Lindbom, Lu Karolinska Institutet4 aut |
700 | 1 | a Alm, Peru Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-pal |
700 | 1 | a Björck, Larsu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-lbj |
700 | 1 | a Herwald, Heikou Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-hhe |
710 | 2 | a Institutionen för experimentell medicinsk vetenskapb Medicinska fakulteten4 org |
773 | 0 | t Journal of Experimental Medicined : Rockefeller University Pressg 192:10, s. 1415-1424q 192:10<1415-1424x 1540-9538x 0022-1007 |
856 | 4 | u http://www.jem.org/cgi/content/full/192/10/1415y FULLTEXT |
856 | 4 | u http://jem.rupress.org/content/jem/192/10/1415.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1116236 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1939957 |
856 | 4 8 | u https://doi.org/10.1084/jem.192.10.1415 |
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