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Metabolic control b...
Metabolic control by AMPK in white adipose tissue
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- Göransson, Olga (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Proteinfosforylering,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Protein Phosphorylation,Lund University Research Groups
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- Kopietz, Franziska (author)
- Lund University,Lunds universitet,Glukostransport och proteintrafficking,Forskargrupper vid Lunds universitet,Glucose Transport and Protein Trafficking,Lund University Research Groups
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- Rider, Mark H. (author)
- Catholic University of Louvain
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(creator_code:org_t)
- 2023
- 2023
- English 14 s.
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In: Trends in Endocrinology and Metabolism. - 1043-2760. ; 34:11, s. 704-717
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Abstract
Subject headings
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- White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- adipocyte
- AMPK
- Drug targeting
- glucose uptake
- lipogenesis
- lipolysis
Publication and Content Type
- for (subject category)
- ref (subject category)
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