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The immunosuppressa...
The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain
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- Drake, M. (author)
- Skåne University Hospital
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- Friberg, H. (author)
- Lund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Boris-Möller, F. (author)
- Lund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Sakata, K. (author)
- Lund University,Skåne University Hospital
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- Wieloch, T. (author)
- Lund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 1996
- 1996
- English 5 s.
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In: Acta Physiologica Scandinavica. - 0001-6772. ; 158:2, s. 155-159
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg-1 by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting calcineurin-mediated events or by preserving mitochondrial function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- FK506
- Glutamate
- Immunophilin
- Ischaemia
- Mitochondria
- Neuronal death
Publication and Content Type
- art (subject category)
- ref (subject category)
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