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  • Ji, YingjieUniversity of Exeter,Royal Devon & Exeter Hospital (author)

Genome-wide and abdominal MRI data provide evidence that a genetically determined favorable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease, and hypertension

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2018-10-23
  • American Diabetes Association,2019
  • 13 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2408569c-f6a8-4008-be4d-2bb61336b6d5
  • https://lup.lub.lu.se/record/2408569c-f6a8-4008-be4d-2bb61336b6d5URI
  • https://doi.org/10.2337/db18-0708DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155088URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined MRI data with genome-wide association studies of body fat percentage (%) and metabolic traits. We report 14 alleles, including 7 newly characterized alleles, associated with higher adiposity but a favorable metabolic profile. Consistent with previous studies, individuals carrying more favorable adiposity alleles had higher body fat % and higher BMI but lower risk of type 2 diabetes, heart disease, and hypertension. These individuals also had higher subcutaneous fat but lower liver fat and a lower visceral-to-subcutaneous adipose tissue ratio. Individual alleles associated with higher body fat % but lower liver fat and lower risk of type 2 diabetes included those in PPARG, GRB14, and IRS1, whereas the allele in ANKRD55 was paradoxically associated with higher visceral fat but lower risk of type 2 diabetes. Most identified favorable adiposity alleles are associated with higher subcutaneous and lower liver fat, a mechanism consistent with the beneficial effects of storing excess triglycerides in metabolically low-risk depots.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Yiorkas, Andrianos M.Brunel University London,Imperial College London (author)
  • Frau, FrancescaSanofi-Aventis Deutschland GmbH (author)
  • Mook-Kanamori, DennisLeiden University Medical Centre (author)
  • Staiger, HaraldUniversity of Tübingen,German Center for Diabetes Research (author)
  • Thomas, E. LouiseUniversity of Westminster (author)
  • Atabaki-Pasdar, NaeimehLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-nha (author)
  • Campbell, ArchieUniversity of Edinburgh (author)
  • Tyrrell, JessicaUniversity of Exeter (author)
  • Jones, Samuel E.University of Exeter (author)
  • Beaumont, Robin N.University of Exeter (author)
  • Wood, Andrew R.University of Exeter (author)
  • Tuke, Marcus A.University of Exeter (author)
  • Ruth, Katherine S.University of Exeter (author)
  • Mahajan, AnubhaWellcome Trust Centre for Human Genetics (author)
  • Murray, AnnaUniversity of Exeter (author)
  • Freathy, Rachel M.University of Exeter (author)
  • Weedon, Michael N.University of Exeter (author)
  • Hattersley, Andrew T.University of Exeter (author)
  • Hayward, CarolineUniversity of Edinburgh (author)
  • Machann, JürgenGerman Center for Diabetes Research,University of Tübingen (author)
  • Häring, Hans UlrichUniversity of Tübingen,German Center for Diabetes Research (author)
  • Franks, PaulUmeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA,Harvard University,Medicin(Swepub:umu)pafr0003 (author)
  • de Mutsert, RenéeLeiden University Medical Centre (author)
  • Pearson, EwanNinewells Hospital and Medical School,University of Dundee (author)
  • Stefan, NorbertGerman Center for Diabetes Research,University of Tübingen (author)
  • Frayling, Timothy M.University of Exeter (author)
  • Allebrandt, Karla V.Sanofi-Aventis Deutschland GmbH (author)
  • Bell, Jimmy D.University of Westminster (author)
  • Blakemore, Alexandra I.Brunel University London,Imperial College London (author)
  • Yaghootkar, HaniehUniversity of Exeter (author)
  • University of ExeterRoyal Devon & Exeter Hospital (creator_code:org_t)

Related titles

  • In:Diabetes: American Diabetes Association68:1, s. 207-2190012-17971939-327X

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