Search: onr:"swepub:oai:lup.lub.lu.se:2412aec0-a959-45b4-af46-210b1dcb655b" >
Postmortem imaging ...
Postmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer’s disease
-
- Ravikumar, Sadhana (author)
- Hospital of the University of Pennsylvania
-
- Denning, Amanda E. (author)
- Hospital of the University of Pennsylvania
-
- Lim, Sydney (author)
- Hospital of the University of Pennsylvania
-
show more...
-
- Chung, Eunice (author)
- Hospital of the University of Pennsylvania
-
- Sadeghpour, Niyousha (author)
- Hospital of the University of Pennsylvania
-
- Ittyerah, Ranjit (author)
- Hospital of the University of Pennsylvania
-
- Wisse, Laura E.M. (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas
-
- Das, Sandhitsu R. (author)
- University of Pennsylvania
-
- Xie, Long (author)
- Hospital of the University of Pennsylvania
-
- Robinson, John L. (author)
- University of Pennsylvania
-
- Schuck, Theresa (author)
- University of Pennsylvania
-
- Lee, Edward B. (author)
- University of Pennsylvania
-
- Detre, John A. (author)
- University of Pennsylvania
-
- Tisdall, M. Dylan (author)
- Hospital of the University of Pennsylvania
-
- Prabhakaran, Karthik (author)
- University of Pennsylvania
-
- Mizsei, Gabor (author)
- Hospital of the University of Pennsylvania
-
- de Onzono Martin, Maria Mercedes Iñiguez (author)
- University of Castilla La Mancha
-
- Arroyo Jiménez, Maria del Mar (author)
- University of Castilla La Mancha
-
- Mũnoz, Monica (author)
- University of Castilla La Mancha
-
- Marcos Rabal, Maria del Pilar (author)
- University of Castilla La Mancha
-
- Cebada Sánchez, Sandra (author)
- University of Castilla La Mancha
-
- Delgado González, José Carlos (author)
- University of Castilla La Mancha
-
- de la Rosa Prieto, Carlos (author)
- University of Castilla La Mancha
-
- Irwin, David J. (author)
- University of Pennsylvania
-
- Wolk, David A. (author)
- University of Pennsylvania
-
- Insausti, Ricardo (author)
- University of Castilla La Mancha
-
- Yushkevich, Paul A. (author)
- Hospital of the University of Pennsylvania
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Nature Communications. - 2041-1723. ; 15:1
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Our current understanding of the spread and neurodegenerative effects of tau neurofibrillary tangles (NFTs) within the medial temporal lobe (MTL) during the early stages of Alzheimer’s Disease (AD) is limited by the presence of confounding non-AD pathologies and the two-dimensional (2-D) nature of conventional histology studies. Here, we combine ex vivo MRI and serial histological imaging from 25 human MTL specimens to present a detailed, 3-D characterization of quantitative NFT burden measures in the space of a high-resolution, ex vivo atlas with cytoarchitecturally-defined subregion labels, that can be used to inform future in vivo neuroimaging studies. Average maps show a clear anterior to poster gradient in NFT distribution and a precise, spatial pattern with highest levels of NFTs found not just within the transentorhinal region but also the cornu ammonis (CA1) subfield. Additionally, we identify granular MTL regions where measures of neurodegeneration are likely to be linked to NFTs specifically, and thus potentially more sensitive as early AD biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ravikumar, Sadha ...
-
Denning, Amanda ...
-
Lim, Sydney
-
Chung, Eunice
-
Sadeghpour, Niyo ...
-
Ittyerah, Ranjit
-
show more...
-
Wisse, Laura E.M ...
-
Das, Sandhitsu R ...
-
Xie, Long
-
Robinson, John L ...
-
Schuck, Theresa
-
Lee, Edward B.
-
Detre, John A.
-
Tisdall, M. Dyla ...
-
Prabhakaran, Kar ...
-
Mizsei, Gabor
-
de Onzono Martin ...
-
Arroyo Jiménez, ...
-
Mũnoz, Monica
-
Marcos Rabal, Ma ...
-
Cebada Sánchez, ...
-
Delgado González ...
-
de la Rosa Priet ...
-
Irwin, David J.
-
Wolk, David A.
-
Insausti, Ricard ...
-
Yushkevich, Paul ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Nature Communica ...
- By the university
-
Lund University