onr:"swepub:oai:lup.lub.lu.se:24354741-4cf9-45d6-8dc1-3aedd6d56a84"
Search: onr:"swepub:oai:lup.lub.lu.se:24354741-4cf9-45d6-8dc1-3aedd6d56a84" > Consequences of par...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Olito, ColinLund University,Lunds universitet,Evolutionär ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Könsskillnadernas genetik,Forskargrupper vid Lunds universitet,Evolutionary ecology,Department of Biology,Faculty of Science,Genetics of Sex Differences,Lund University Research Groups (author)
Consequences of partially recessive deleterious genetic variation for the evolution of inversions suppressing recombination between sex chromosomes
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-05
- Wiley,2022
- 11 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:24354741-4cf9-45d6-8dc1-3aedd6d56a84
- https://lup.lub.lu.se/record/24354741-4cf9-45d6-8dc1-3aedd6d56a84URI
- https://doi.org/10.1111/evo.14496DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The evolution of suppressed recombination between sex chromosomes is widely hypothesized to be driven by sexually antagonistic selection (SA), where tighter linkage between the sex-determining gene(s) and nearby SA loci is favored when it couples male-beneficial alleles to the proto-Y chromosome, and female-beneficial alleles to the proto-X. Despite limited empirical evidence, the SA selection hypothesis overshadows several alternatives, including an incomplete but often-repeated “sheltering hypothesis” that suggests that expansion of the sex-linked region (SLR) reduces homozygous expression of partially recessive deleterious mutations at selected loci. Here, we use population genetic models to evaluate the consequences of deleterious mutational variation for the evolution of neutral chromosomal inversions expanding the SLR on proto-Y chromosomes. We find that SLR-expanding inversions face a race against time: lightly loaded inversions are initially beneficial, but eventually become deleterious as they accumulate new mutations, and must fix before this window of opportunity closes. The outcome of this race is strongly influenced by inversion size, the mutation rate, and the dominance coefficient of deleterious mutations. Yet, small inversions have elevated fixation probabilities relative to neutral expectations for biologically plausible parameter values. Our results demonstrate that deleterious genetic variation can plausibly drive recombination suppression in small steps and would be most consistent with empirical patterns of small evolutionary strata or gradual recombination arrest.
Subject headings and genre
- NATURVETENSKAP Biologi Evolutionsbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Evolutionary Biology hsv//eng
- Chromosomal inversion
- indirect selection
- mutation
- recombination suppression
- sex chromosomes
Added entries (persons, corporate bodies, meetings, titles ...)
- Ponnikas, SuviLund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science,University of Oulu(Swepub:lu)su1473po (author)
- Hansson, BengtLund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Könsskillnadernas genetik,Forskargrupper vid Lunds universitet,Department of Biology,Faculty of Science,Genetics of Sex Differences,Lund University Research Groups(Swepub:lu)ekol-bhn (author)
- Abbott, Jessica K.Lund University,Lunds universitet,Evolutionär ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Könsskillnadernas genetik,Forskargrupper vid Lunds universitet,Evolutionary ecology,Department of Biology,Faculty of Science,Genetics of Sex Differences,Lund University Research Groups(Swepub:lu)zooe-jab (author)
- Evolutionär ekologiBiologiska institutionen (creator_code:org_t)
Related titles
- In:Evolution: Wiley76:6, s. 1320-13300014-38201558-5646
Internet link
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Olito, Colin
- Ponnikas, Suvi
- Hansson, Bengt
- Abbott, Jessica ...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Evolutionary Bio ...
- Articles in the publication
- Evolution
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
