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External validation...
External validation of postoperative pancreatic fistula prediction scores in pancreatoduodenectomy : a systematic review and meta-analysis
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- Pande, Rupaly (author)
- New Queen Elizabeth Hospital
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- Halle-Smith, James M. (author)
- New Queen Elizabeth Hospital
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- Phelan, Liam (author)
- New Queen Elizabeth Hospital
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- Thorne, Thomas (author)
- New Queen Elizabeth Hospital
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- Panikkar, M. (author)
- New Queen Elizabeth Hospital
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- Hodson, James (author)
- New Queen Elizabeth Hospital
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- Roberts, Keith J. (author)
- University of Birmingham,New Queen Elizabeth Hospital
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- Arshad, Ali (author)
- University Hospital Southampton
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- Connor, Saxon (author)
- Christchurch Hospital New Zealand
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- Conlon, Kevin CP (author)
- Trinity College Dublin
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- Dickson, Euan J. (author)
- Glasgow Royal Infirmary
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- Giovinazzo, Francesco (author)
- Policlinico Universitario Agostino Gemelli
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- Harrison, Ewen (author)
- University of Edinburgh
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- de Liguori Carino, Nicola (author)
- Manchester University NHS Foundation Trust
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- Hore, Todd (author)
- Christchurch Hospital New Zealand
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- Knight, Stephen R. (author)
- University of Edinburgh
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- Loveday, Benjamin (author)
- Royal Melbourne Hospital
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- Magill, Laura (author)
- University of Birmingham
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- Mirza, Darius (author)
- New Queen Elizabeth Hospital
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- Pandanaboyana, Sanjay (author)
- Freeman Hospital
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- Perry, Rita J. (author)
- University of Birmingham
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- Pinkney, Thomas (author)
- University of Birmingham
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- Siriwardena, Ajith K. (author)
- Manchester University NHS Foundation Trust
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- Satoi, Sohei (author)
- University of Colorado,Kansai Medical University
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Skipworth, James (author)
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Stättner, Stefan (author)
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- Sutcliffe, Robert P. (author)
- New Queen Elizabeth Hospital
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- Tingstedt, Bobby (author)
- Lund University,Lunds universitet,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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(creator_code:org_t)
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- Elsevier BV, 2022
- 2022
- English.
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In: HPB. - : Elsevier BV. - 1365-182X. ; 24:3, s. 287-298
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background: Multiple risk scores claim to predict the probability of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy. It is unclear which scores have undergone external validation and are the most accurate. The aim of this study was to identify risk scores for POPF, and assess the clinical validity of these scores. Methods: Areas under receiving operator characteristic curve (AUROCs) were extracted from studies that performed external validation of POPF risk scores. These were pooled for each risk score, using intercept-only random-effects meta-regression models. Results: Systematic review identified 34 risk scores, of which six had been subjected to external validation, and so included in the meta-analysis, (Tokyo (N=2 validation studies), Birmingham (N=5), FRS (N=19), a-FRS (N=12), m-FRS (N=3) and ua-FRS (N=3) scores). Overall predictive accuracies were similar for all six scores, with pooled AUROCs of 0.61, 0.70, 0.71, 0.70, 0.70 and 0.72, respectively. Considerably heterogeneity was observed, with I2 statistics ranging from 52.1-88.6%. Conclusion: Most risk scores lack external validation; where this was performed, risk scores were found to have limited predictive accuracy. Consensus is needed for which score to use in clinical practice. Due to the limited predictive accuracy, future studies to derive a more accurate risk score are warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- By the author/editor
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Pande, Rupaly
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Halle-Smith, Jam ...
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Phelan, Liam
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Thorne, Thomas
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Panikkar, M.
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Hodson, James
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show more...
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Roberts, Keith J ...
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Arshad, Ali
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Connor, Saxon
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Conlon, Kevin CP
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Dickson, Euan J.
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Giovinazzo, Fran ...
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Harrison, Ewen
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de Liguori Carin ...
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Hore, Todd
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Knight, Stephen ...
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Loveday, Benjami ...
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Magill, Laura
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Mirza, Darius
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Pandanaboyana, S ...
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Perry, Rita J.
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Pinkney, Thomas
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Siriwardena, Aji ...
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Satoi, Sohei
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Skipworth, James
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Stättner, Stefan
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Sutcliffe, Rober ...
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Tingstedt, Bobby
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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HPB
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Lund University