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  • Traulsen, Lisbet KroghUniversity of Southern Denmark (author)

Determinants of persistent asthma in young adults

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-06-05
  • Informa UK Limited,2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:24df576d-c7aa-4850-98c1-38884c81c81c
  • https://lup.lub.lu.se/record/24df576d-c7aa-4850-98c1-38884c81c81cURI
  • https://doi.org/10.1080/20018525.2018.1478593DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: The aim of the study was to evaluate determinants for the prognosis of asthma in a population-based cohort of young adults. Design: The study was a nine-year clinical follow up of 239 asthmatic subjects from an enriched population-based sample of 1,191 young adults, aged 20-44 years, who participated in an interviewer-administered questionnaire and clinical examination at baseline in 2003-2006. From the interview, an asthma score was generated as the simple sum of affirmative answers to five main asthma-like symptoms in order to analyse symptoms of asthma as a continuum. The clinical examination comprised spirometry, bronchial challenge or bronchodilation, and skin prick test. Results: Among the 239 individuals with asthma at baseline 164 (69%) had persistent asthma at follow up, while 68 (28%) achieved remission of asthma and seven (3%) were diagnosed with COPD solely. Determinants for persistent asthma were use of medication for breathing within the last 12 months: Short-acting beta-adrenoceptor agonists (SABA) only (OR 3.39; 95%CI: 1.47-7.82) and inhaled corticosteroids (ICS) and/or long-acting beta-adrenoceptor agonists (LABA) (8.95; 3.87-20.69). Stratified by age of onset determinants for persistence in individuals with early-onset asthma (age less than 16 years) were FEV₁ below predicted (7.12; 1.61-31.50), asthma score at baseline (2.06; 1.15-3.68) and use of ICS and/or LABA within 12 months (9.87; 1.95-49.98). In individuals with late-onset asthma the determinant was use of ICS and/or LABA within 12 months (6.84; 2.09-22.37). Conclusions: Pulmonary function below predicted, severity of disease expressed by asthma score and use of ICS and/or LABA were all determinants for persistent early-onset asthma, whereas only use of ICS and/or LABA was a determinant in late-onset asthma. A high asthma score indicated insufficient disease control in a substantial proportion of these young adults.

Subject headings and genre

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  • Halling, AndersLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups(Swepub:lu)med-ahn (author)
  • Bælum, JesperUniversity of Southern Denmark (author)
  • Davidsen, Jesper RømhildOdense University Hospital (author)
  • Miller, MartinUniversity of Birmingham (author)
  • Omland, ØyvindAalborg University Hospital (author)
  • Sherson, DavidOdense University Hospital (author)
  • Sigsgaard, TorbenAarhus University Hospital (author)
  • Thilsing, Trine (author)
  • Thomsen, GertHospital of South West Jutland, Esbjerg (author)
  • Skadhauge, Lars Rauff (author)
  • University of Southern DenmarkAllmänmedicin och samhällsmedicin (creator_code:org_t)

Related titles

  • In:European clinical respiratory journal: Informa UK Limited5:1, s. 1-92001-8525

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