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  • Malmström, ErikLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine (author)

The importance of fibroblasts in remodelling of the human uterine cervix during pregnancy and parturition.

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-03-02
  • Oxford University Press (OUP),2007

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:253dcdb9-cc24-4e65-9b1b-28e25071ca99
  • https://lup.lub.lu.se/record/166830URI
  • https://doi.org/10.1093/molehr/gal117DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115590566URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • It is well established that fibroblasts play a crucial role in pathophysiological extracellular matrix remodelling. The aim of this project is to elucidate their role in normal physiological remodelling. Specifically, the remodelling of the human cervix during pregnancy, resulting in an enabled passage of the child, is used as the model system. Fibroblast cultures were established from cervices of non-pregnant women, women after 36 weeks of pregnancy and women directly after partus. The cells were immunostained and quantified by western blots for differentiation markers. The cultures were screened for cytokine and metalloproteinase production and characterized by global proteome analysis. The cell cultures established from partal donors differ significantly from those from non-pregnant donors, which is in accordance with in vivo findings. A decrease in alpha-smooth actin and prolyl-4hydroxylase and an increase in interleukin (IL)-6, IL-8 and matrix metalloproteinases (MMP)-1 and MMP-3 were observed in cultures from partal donors. 2D-gel electrophoresis followed by mass spectrometry showed that the expression of 59 proteins was changed significantly in cultures of partal donors. The regulated proteins are involved in protein kinase C signalling, Ca2+ binding, cytoskeletal organization, angiogenesis and degradation. Our data suggest that remodelling of the human cervix is orchestrated by fibroblasts, which are activated or recruited by the inflammatory processes occurring during the ripening cascade.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Sennstrom, MariaKarolinska Institutet (author)
  • Holmberg, AnnaLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)infe-aho (author)
  • Frielingsdorf, HelenaLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mphy-hfr (author)
  • Eklund, ErikLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)medk-eek (author)
  • Malmstrom, Lars (author)
  • Tufvesson, EllenLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lungfysiologi och biomarkörer,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lung physiology and biomarkers,Lund University Research Groups(Swepub:lu)medk-etu (author)
  • Gomez, MariaLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)mphy-mgo (author)
  • Westergren-Thorsson, GunillaLund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups(Swepub:lu)medk-gwt (author)
  • Ekman-Ordeberg, GunvorKarolinska Institutet (author)
  • Malmstrom, Anders (author)
  • InfektionsmedicinSektion III (creator_code:org_t)

Related titles

  • In:Molecular Human Reproduction: Oxford University Press (OUP)13, s. 333-3411460-2407
  • In:MHR: Basic science of reproductive medicine: Oxford University Press (OUP)13, s. 333-3411360-9947

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