Spontaneous muscle twitches during sleep guide spinal self-organization.

Petersson, PerLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups (author)

During development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through unknown adaptive mechanisms. In spinal reflex systems, this enables the fast transformation of complex sensory information into adequate correction of movements. Here we use a computer simulation to show that an unsupervised correlation-based learning mechanism, using spontaneous muscle twitches, can account for the functional adaptation of the withdrawal reflex system. We also show that tactile feedback resulting from spontaneous muscle twitches during sleep(1-3) does indeed modify sensorimotor transformation in young rats in a predictable manner. The results indicate that these twitches, corresponding to human fetal movements(4), are important in spinal self-organization.

Waldenström Ellervik, AlexandraLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups(Swepub:lu)mphy-awa (author)
Fåhraeus, ChristerLund University,Lunds universitet,Hjärnans sensorimotoriska funktioner,Forskargrupper vid Lunds universitet,Neural Basis of Sensorimotor Control,Lund University Research Groups(Swepub:lu)ch5588fa (author)
Schouenborg, JensLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups(Swepub:lu)mphy-jsc (author)
NeurofysiologiForskargrupper vid Lunds universitet (creator_code:org_t)

In:Nature: Springer Science and Business Media LLC424:6944, s. 72-750028-08361476-4687

By the author/editor: Petersson, Per; Waldenström Elle ...; Fåhraeus, Christ ...; Schouenborg, Jen ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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