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Venous thrombosis in children and adolescents with Hodgkin lymphoma in Sweden
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- Schönning, A. (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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- Karlén, J. (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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- Frisk, T (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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- Heyman, M M (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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- Svahn, J. E. (author)
- Lund University,Lunds universitet,Pediatrisk onkologi,Forskargrupper vid Lunds universitet,Pediatric Oncology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden
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- Øra, I. (author)
- Lund University,Lunds universitet,Pediatrisk onkologi,Forskargrupper vid Lunds universitet,Pediatric Oncology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden
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- Kawan, L. (author)
- Sahlgrens University Hospital, Sweden
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- Holmqvist Persson, Britt-Marie (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Region Östergötland, Barn- och ungdomskliniken i Linköping,Linköping University Hospital
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- Björklund, C. (author)
- Norrland University Hospital,Umeå University Hospital, Sweden
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- Harila-Saari, Arja (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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- Ranta, S (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
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(creator_code:org_t)
- Elsevier BV, 2017
- English 5 s.
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In: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 152, s. 64-68
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Abstract
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- Introduction Pediatric patients with Hodgkin lymphoma (HL) have several risk factors for venous thromboembolism (VTE). Although these patients are occasionally treated with thromboprophylaxis, no guidelines are implemented in Sweden. Scarce data from adult patients indicate an increased risk of VTE, but pediatric data is largely missing. Given the favorable overall survival of HL, there should reasonably be more focus on preventing complications. Materials and methods We conducted a retrospective cohort study, including all patients registered in the Childhood Cancer Registry under the age of 18 years diagnosed with HL between January 2005 and December 2015 in Sweden. Results Data was retrieved from the medical records of all 163 patients (100%) at six Swedish pediatric cancer centers. The incidence of VTE was 7.7% (symptomatic VTE 3.9%). The median follow-up was 3.4 years (range 0.3–10.5). Only five patients (3.1%) were treated with thromboprophylaxis. All VTE events occurred in the older age category (11–17 years) and all but one (92.7%) had a mediastinal mass. While the VTE did not significantly affect the treatment of HL, it caused increased morbidity and 2/12 developed a post-thrombotic syndrome. No significant risk factors for VTE were identified. Conclusions VTE is a relatively common complication of HL and its treatment, causing increased acute and long-term morbidity. However, due to limited number of events we could not demonstrate risk-factors for VTE that would identify patients who might benefit from thromboprophylaxis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Adolescents
- Children
- Hodgkin lymphoma
- Venous thromboembolism
- Hodgkin lymphoma; Venous thromboembolism; Children; Adolescents
Publication and Content Type
- art (subject category)
- ref (subject category)
To the university's database
- By the author/editor
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Schönning, A.
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Karlén, J.
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Frisk, T
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Heyman, M M
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Svahn, J. E.
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Øra, I.
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Kawan, L.
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Holmqvist Persso ...
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Björklund, C.
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Harila-Saari, Ar ...
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Ranta, S
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Thrombosis Resea ...
- By the university
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Lund University
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Linköping University
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Karolinska Institutet