Search: onr:"swepub:oai:lup.lub.lu.se:259b90c6-94ad-4874-bad5-584c73ffa09e" >
Rationale and desig...
Rationale and design of the Cyclosporine to ImpRove Clinical oUtcome in ST-elevation myocardial infarction patients (the CIRCUS trial)
- Article/chapterEnglish2015
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:259b90c6-94ad-4874-bad5-584c73ffa09e
-
https://lup.lub.lu.se/record/7410529URI
-
https://doi.org/10.1016/j.ahj.2015.02.020DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background Both acute myocardial ischemia and reperfusion contribute to cardiomyocyte death in ST-elevation myocardial infarction (STEMI). The final infarct size is the principal determinant of subsequent clinical outcome in STEMI patients. In a proof-of-concept phase II trial, the administration of cyclosporine prior to primary percutaneous coronary intervention (PPCI) has been associated with a reduction of infarct size in STEMI patients. Methods CIRCUS is an international, prospective, multicenter, randomized, double-blinded, placebo-controlled trial. The study is designed to compare the efficacy and safety of cyclosporine versus placebo, in addition to revascularization by PPCI, in patients presenting with acute anterior myocardial infarction within 12 hours of symptoms onset and initial TIMI flow <= 1 in the culprit left anterior descending coronary artery. Patients are randomized in a 1: 1 fashion to 2.5 mg/kg intravenous infusion of cyclosporine or matching placebo performed in theminutes preceding PCI. The primary efficacy end point of CIRCUS is a composite of 1-year all-cause mortality, rehospitalization for heart failure or heart failure worsening during initial hospitalization, and left ventricular adverse remodeling as determined by sequential transthoracic echochardiography. Secondary outcomes will be tested using a hierarchical sequence of left ventricular (LV) ejection fraction and absolute measurements of LV volumes. The composite of death and rehospitalization for heart failure or heart failure worsening during initial hospitalization will be further assessed at three years after the initial infarction. Results Recruitment lasted from April 2011 to February 2014. The CIRCUS trial has recruited 975 patients with acute anterior myocardial infarction. The 12-months results are expected to be available in 2015. Conclusions The CIRCUS trial is testing the hypothesis that cyclosporine in addition to early revascularization with PPCI compared to placebo in patients with acute anterior myocardial infarction reduces the incidence of death, heart failure and adverse LV remodeling at one-year follow-up.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Cung, Thien T.
(author)
-
Morel, Olivier
(author)
-
Cayla, Guillaume
(author)
-
Bonnefoy-Cudraz, Eric
(author)
-
Rioufol, Gilles
(author)
-
Angoulvant, Denis
(author)
-
Guerin, Patrice
(author)
-
Elbaz, Meyer
(author)
-
Delarche, Nicolas
(author)
-
Coste, Pierre
(author)
-
Vanzetto, Gerald
(author)
-
Metge, Marc
(author)
-
Aupetit, Jean-Francois
(author)
-
Jouve, Bernard
(author)
-
Motreff, Pascal
(author)
-
Tron, Christophe
(author)
-
Labeque, Jean-Noel
(author)
-
Steg, Pierre G.
(author)
-
Cottin, Yves
(author)
-
Range, Gregoire
(author)
-
Clerc, Jerome
(author)
-
Coussement, Patrick
(author)
-
Prunier, Fabrice
(author)
-
Moulin, Frederique
(author)
-
Roth, Olivier
(author)
-
Belle, Loic
(author)
-
Dubois, Phillipe
(author)
-
Barragan, Paul
(author)
-
Gilard, Martine
(author)
-
Piot, Christophe
(author)
-
Colin, Patrice
(author)
-
Morice, Marie-Claude
(author)
-
Monassier, Jean-Pierre
(author)
-
Ider, Omar
(author)
-
Dubois-Rande, Jean Luc P.
(author)
-
Unterseeh, Thierry
(author)
-
Lebreton, Herve
(author)
-
Beard, Thierry
(author)
-
Blanchard, Didier
(author)
-
Grollier, Gilles
(author)
-
Malquarti, Vincent
(author)
-
Staat, Patrick
(author)
-
Sudre, Arnaud
(author)
-
Hansson, MagnusLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)expb-mha
(author)
-
Elmer, EskilLund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)expb-eel
(author)
-
Boussaha, Inesse
(author)
-
Jossan, Claire
(author)
-
Torner, Anna
(author)
-
Claeys, Marc
(author)
-
Garcia-Dorado, David
(author)
-
Ovize, Michel
(author)
-
Klinisk fysiologi, LundSektion V
(creator_code:org_t)
Related titles
-
In:American Heart Journal: Elsevier BV169:6, s. 6-7661097-67440002-8703
Internet link
Find in a library
To the university's database
- By the author/editor
-
Mewton, Nathan
-
Cung, Thien T.
-
Morel, Olivier
-
Cayla, Guillaume
-
Bonnefoy-Cudraz, ...
-
Rioufol, Gilles
-
show more...
-
Angoulvant, Deni ...
-
Guerin, Patrice
-
Elbaz, Meyer
-
Delarche, Nicola ...
-
Coste, Pierre
-
Vanzetto, Gerald
-
Metge, Marc
-
Aupetit, Jean-Fr ...
-
Jouve, Bernard
-
Motreff, Pascal
-
Tron, Christophe
-
Labeque, Jean-No ...
-
Steg, Pierre G.
-
Cottin, Yves
-
Range, Gregoire
-
Clerc, Jerome
-
Coussement, Patr ...
-
Prunier, Fabrice
-
Moulin, Frederiq ...
-
Roth, Olivier
-
Belle, Loic
-
Dubois, Phillipe
-
Barragan, Paul
-
Gilard, Martine
-
Piot, Christophe
-
Colin, Patrice
-
Morice, Marie-Cl ...
-
Monassier, Jean- ...
-
Ider, Omar
-
Dubois-Rande, Je ...
-
Unterseeh, Thier ...
-
Lebreton, Herve
-
Beard, Thierry
-
Blanchard, Didie ...
-
Grollier, Gilles
-
Malquarti, Vince ...
-
Staat, Patrick
-
Sudre, Arnaud
-
Hansson, Magnus
-
Elmer, Eskil
-
Boussaha, Inesse
-
Jossan, Claire
-
Torner, Anna
-
Claeys, Marc
-
Garcia-Dorado, D ...
-
Ovize, Michel
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
American Heart J ...
- By the university
-
Lund University